Afatinib impurity 11

Modify Date: 2025-08-27 18:30:05

Afatinib impurity 11 Structure
Afatinib impurity 11 structure
 Common Name Afatinib impurity 11
CAS Number 1402086-20-7 Molecular Weight 428.84
Density N/A Boiling Point N/A
Molecular Formula C21H18ClFN4O3 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Afatinib impurity 11


Afatinib impurity 11 is an impurity of Afatinib. Afatinib is an irreversible EGFR family inhibitor with IC50s of 0.5 nM, 0.4 nM, 10 nM and 14 nM for EGFRwt, EGFRL858R, EGFRL858R/T790M and HER2, respectively[1].

 Names

Name Afatinib impurity 11

 Afatinib impurity 11 Biological Activity

Description Afatinib impurity 11 is an impurity of Afatinib. Afatinib is an irreversible EGFR family inhibitor with IC50s of 0.5 nM, 0.4 nM, 10 nM and 14 nM for EGFRwt, EGFRL858R, EGFRL858R/T790M and HER2, respectively[1].
Related Catalog
References

[1]. Li D, et al. BIBW2992, an irreversible EGFR/HER2 inhibitor highly effective in preclinical lung cancer models. Oncogene. 2008 Aug 7;27(34):4702-11.

 Chemical & Physical Properties

Molecular Formula C21H18ClFN4O3
Molecular Weight 428.84
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