Afatinib impurity 11

Names

[ CAS No. ]:
1402086-20-7

[ Name ]:
Afatinib impurity 11

Biological Activity

[Description]:

Afatinib impurity 11 is an impurity of Afatinib. Afatinib is an irreversible EGFR family inhibitor with IC50s of 0.5 nM, 0.4 nM, 10 nM and 14 nM for EGFRwt, EGFRL858R, EGFRL858R/T790M and HER2, respectively[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> JAK/STAT Signaling >> EGFR

Signaling Pathways >> Protein Tyrosine Kinase/RTK >> EGFR

Signaling Pathways >> Autophagy >> Autophagy

[References]

[1]. Li D, et al. BIBW2992, an irreversible EGFR/HER2 inhibitor highly effective in preclinical lung cancer models. Oncogene. 2008 Aug 7;27(34):4702-11.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₁H₁₈ClFN₄O₃

[ Molecular Weight ]:
428.84

Related Compounds

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