sulfo-DGN462 sodium

Modify Date: 2024-01-12 13:13:35

sulfo-DGN462 sodium structure	Common Name	sulfo-DGN462 sodium
	CAS Number	1401203-09-5	Molecular Weight	1046.19
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₅₃H₆₀N₅NaO₁₂S₂	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of sulfo-DGN462 sodium

sulfo-DGN462 sodium is degraded to DGN462 in culture medium and plasma. DGN462, a potent DNA-alkylating agent, shows anti-tumor activity, such as acute myeloid leukemia (AML)[1].

Name	sulfo-DGN462 sodium

Description	sulfo-DGN462 sodium is degraded to DGN462 in culture medium and plasma. DGN462, a potent DNA-alkylating agent, shows anti-tumor activity, such as acute myeloid leukemia (AML)[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Antibody-drug Conjugate >> ADC Cytotoxin Signaling Pathways >> Cell Cycle/DNA Damage >> DNA Alkylator/Crosslinker
In Vitro	DGN462 can be used as a cytotoxic component of antibody-drug conjugates (ADCs). DGN462 is a member of the DNA-alkylating indolinobenzodiazepine pseudodimers (IGNs) class[1].
References	[1]. Hicks SW, et al. The novel CD19-targeting antibody-drug conjugate huB4-DGN462 shows improved anti-tumor activity compared to SAR3419 in CD19-positive lymphoma and leukemia models. Haematologica. 2019 Aug;104(8):1633-1639.

Molecular Formula	C₅₃H₆₀N₅NaO₁₂S₂
Molecular Weight	1046.19