sulfo-DGN462 sodium

Modify Date: 2025-08-23 18:42:21

sulfo-DGN462 sodium Structure
sulfo-DGN462 sodium structure
 Common Name sulfo-DGN462 sodium
CAS Number 1401203-09-5 Molecular Weight 1046.19
Density N/A Boiling Point N/A
Molecular Formula C53H60N5NaO12S2 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of sulfo-DGN462 sodium


sulfo-DGN462 sodium is degraded to DGN462 in culture medium and plasma. DGN462, a potent DNA-alkylating agent, shows anti-tumor activity, such as acute myeloid leukemia (AML)[1].

 Names

Name sulfo-DGN462 sodium

 sulfo-DGN462 sodium Biological Activity

Description sulfo-DGN462 sodium is degraded to DGN462 in culture medium and plasma. DGN462, a potent DNA-alkylating agent, shows anti-tumor activity, such as acute myeloid leukemia (AML)[1].
Related Catalog
In Vitro DGN462 can be used as a cytotoxic component of antibody-drug conjugates (ADCs). DGN462 is a member of the DNA-alkylating indolinobenzodiazepine pseudodimers (IGNs) class[1].
References

[1]. Hicks SW, et al. The novel CD19-targeting antibody-drug conjugate huB4-DGN462 shows improved anti-tumor activity compared to SAR3419 in CD19-positive lymphoma and leukemia models. Haematologica. 2019 Aug;104(8):1633-1639.

 Chemical & Physical Properties

Molecular Formula C53H60N5NaO12S2
Molecular Weight 1046.19
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Chemsrc provides sulfo-DGN462 sodium(CAS#:1401203-09-5) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of sulfo-DGN462 sodium are included as well.>> amp version: sulfo-DGN462 sodium

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