Tenuifoliside A

Modify Date: 2024-01-03 18:40:12

Tenuifoliside A Structure
Tenuifoliside A structure
Common Name Tenuifoliside A
CAS Number 139726-35-5 Molecular Weight 682.623
Density 1.6±0.1 g/cm3 Boiling Point 917.3±65.0 °C at 760 mmHg
Molecular Formula C31H38O17 Melting Point N/A
MSDS N/A Flash Point 291.4±27.8 °C

 Use of Tenuifoliside A


Tenuifoliside A is isolated from Polygala tenuifolia, has anti-apoptotic and antidepressant-like effects. Tenuifoliside A exhibits its neneurotrophic effects and promotes cell proliferation through the ERK/CREB/BDNF signal pathway in C6 cells[1].

 Names

Name Tenuifoliside A
Synonym More Synonyms

 Tenuifoliside A Biological Activity

Description Tenuifoliside A is isolated from Polygala tenuifolia, has anti-apoptotic and antidepressant-like effects. Tenuifoliside A exhibits its neneurotrophic effects and promotes cell proliferation through the ERK/CREB/BDNF signal pathway in C6 cells[1].
Related Catalog
In Vitro Tenuifoliside A (6-30 μM; 24 hours) increases the C6 cells viability significantly by concentration dependent manner. But the viability of the 60 μM treatment group is suppressed. Only 60 μM TFSA induced the release of LDH, shows a toxic effect[1]. Tenuifoliside A (10 μM; 2, 5, 7, 10, 15, 30, 45 and 60 mins) elicits a rapid (starting at 2 min) and marked induction of ERK1/2 phosphorylation peaking at 5 min. And,the enhanced levels of phospho-ERK induced by TFSA are partially blocked by ERK inhibitor U0126[1].
References

[1]. Dong XZ, et al. Effect of Tenuifoliside A isolated from Polygala tenuifolia on the ERK and PI3K pathways in C6 glioma cells. Phytomedicine. 2014 Sep 15;21(10):1178-88.

 Chemical & Physical Properties

Density 1.6±0.1 g/cm3
Boiling Point 917.3±65.0 °C at 760 mmHg
Molecular Formula C31H38O17
Molecular Weight 682.623
Flash Point 291.4±27.8 °C
Exact Mass 682.210876
PSA 249.59000
LogP 3.91
Vapour Pressure 0.0±0.3 mmHg at 25°C
Index of Refraction 1.648

 Synonyms

3-O-[(2E)-3-(3,4,5-Trimethoxyphenyl)-2-propenoyl]-β-D-fructofuranosyl 6-O-(4-hydroxybenzoyl)-α-D-glucopyranoside
α-D-Glucopyranoside, 3-O-[(2E)-1-oxo-3-(3,4,5-trimethoxyphenyl)-2-propen-1-yl]-β-D-fructofuranosyl, 6-(4-hydroxybenzoate)