Tenuifoliside A

Names

[ Name ]:
Tenuifoliside A

[Synonym ]:
3-O-[(2E)-3-(3,4,5-Trimethoxyphenyl)-2-propenoyl]-β-D-fructofuranosyl 6-O-(4-hydroxybenzoyl)-α-D-glucopyranoside
α-D-Glucopyranoside, 3-O-[(2E)-1-oxo-3-(3,4,5-trimethoxyphenyl)-2-propen-1-yl]-β-D-fructofuranosyl, 6-(4-hydroxybenzoate)

Biological Activity

[Description]:

Tenuifoliside A is isolated from Polygala tenuifolia, has anti-apoptotic and antidepressant-like effects. Tenuifoliside A exhibits its neneurotrophic effects and promotes cell proliferation through the ERK/CREB/BDNF signal pathway in C6 cells[1].

[Related Catalog]:

Signaling Pathways >> MAPK/ERK Pathway >> ERK

Research Areas >> Neurological Disease

Signaling Pathways >> Stem Cell/Wnt >> ERK

[In Vitro]

Tenuifoliside A (6-30 μM; 24 hours) increases the C6 cells viability significantly by concentration dependent manner. But the viability of the 60 μM treatment group is suppressed. Only 60 μM TFSA induced the release of LDH, shows a toxic effect[1]. Tenuifoliside A (10 μM; 2, 5, 7, 10, 15, 30, 45 and 60 mins) elicits a rapid (starting at 2 min) and marked induction of ERK1/2 phosphorylation peaking at 5 min. And,the enhanced levels of phospho-ERK induced by TFSA are partially blocked by ERK inhibitor U0126[1].

[References]

[1]. Dong XZ, et al. Effect of Tenuifoliside A isolated from Polygala tenuifolia on the ERK and PI3K pathways in C6 glioma cells. Phytomedicine. 2014 Sep 15;21(10):1178-88.

Chemical & Physical Properties

[ Density]:
1.6±0.1 g/cm3

[ Boiling Point ]:
917.3±65.0 °C at 760 mmHg

[ Molecular Formula ]:
C₃₁H₃₈O₁₇

[ Molecular Weight ]:
682.623

[ Flash Point ]:
291.4±27.8 °C

[ Exact Mass ]:
682.210876

[ PSA ]:
249.59000

[ LogP ]:
3.91

[ Vapour Pressure ]:
0.0±0.3 mmHg at 25°C

[ Index of Refraction ]:
1.648

Related Compounds

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