BM-1197
Modify Date: 2025-09-23 17:17:33
BM-1197 structure
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Common Name | BM-1197 | ||
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| CAS Number | 1391107-89-3 | Molecular Weight | 1131.774 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C53H59ClF4N6O7S4 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of BM-1197BM-1197 is a potent, specific dual inhibitor of Bcl-2 and Bcl-xL with Ki of <1 nM, shows >1,000-fold selectivity over Mcl-1; exerts potent growth-inhibitory activity in 7 of 12 small cell lung cancer cell lines tested and induces mechanism-based apoptotic cell death, induces complete and long-lasting tumor regression in vivo. |
| Name | BM-1197 |
|---|
| Description | BM-1197 is a potent, specific dual inhibitor of Bcl-2 and Bcl-xL with Ki of <1 nM, shows >1,000-fold selectivity over Mcl-1; exerts potent growth-inhibitory activity in 7 of 12 small cell lung cancer cell lines tested and induces mechanism-based apoptotic cell death, induces complete and long-lasting tumor regression in vivo. |
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| References | References 1. Bai L, et al. PLoS One. 2014 Jun 5;9(6):e99404. 2. Ye L, et al. Tumour Biol. 2015 May;36(5):3447-55. 3. Acasigua GA, et al. Oral Oncol. 2015 Sep;51(9):839-47. View Related Products by Target Bcl-2 |
| Molecular Formula | C53H59ClF4N6O7S4 |
|---|---|
| Molecular Weight | 1131.774 |
| InChIKey | DMKVQMFONHHNMZ-HUESYALOSA-N |
| SMILES | Cc1c(S(C)(=O)=O)c(-c2cc(F)cc(N3CCN(c4ccc(NS(=O)(=O)c5ccc(NC(CCN6CCC(O)CC6)CSc6ccccc6)c(S(=O)(=O)C(F)(F)F)c5)cc4)CC3)c2)c(-c2ccc(Cl)cc2)n1C(C)C |