2222294-62-2
2222294-62-2 structure
- Name: Bm-MPK1-IN-15b
- Chemical Name: Bm-MPK1-IN-15b
- CAS Number: 2222294-62-2
- Molecular Formula: C22H25N5O2
- Molecular Weight: 391.475
- Create Date: 2020-01-20 11:33:56
- Modify Date: 2023-03-03 21:07:27
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Bm-MPK1-IN-15b is a potent, orally bioavailable inhibitor of B. malayi stress-activated kinase Bm-MPK1 with IC50 of 24 nM; inhibits human p38α and JNK3 with IC50 of 26 and 170 nM, respectively; reduces the motility of adult worms at 100 nM, Bm-MPK1-IN-15b is a tool compound for in vivo studies aimed at strengthening the role of Bm MPK1 in B. malayi response to host oxidative stress.
| Name | Bm-MPK1-IN-15b |
|---|
| Description | Bm-MPK1-IN-15b is a potent, orally bioavailable inhibitor of B. malayi stress-activated kinase Bm-MPK1 with IC50 of 24 nM; inhibits human p38α and JNK3 with IC50 of 26 and 170 nM, respectively; reduces the motility of adult worms at 100 nM, Bm-MPK1-IN-15b is a tool compound for in vivo studies aimed at strengthening the role of Bm MPK1 in B. malayi response to host oxidative stress. |
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| References | References 1. Tummalapalli SR, et al. ACS Med Chem Lett. 2018 Feb 9;9(3):210-214. View Related Products by Target Parasite |
| Molecular Formula | C22H25N5O2 |
|---|---|
| Molecular Weight | 391.475 |