VT-464 (R enantiomer)

Modify Date: 2025-08-25 17:29:05

VT-464 (R enantiomer) structure	Common Name	VT-464 (R enantiomer)
	CAS Number	1375603-38-5	Molecular Weight	399.33900
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₈H₁₇F₄N₃O₃	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of VT-464 (R enantiomer)

Seviteronel (VT-464) R enantiomer is the R enantiomer of Seviteronel (VT-464), which is a potent CYP17 lyase inhibitor(h-Lyase IC50=69 nM); Seviteronel (VT-464) R enantiomer's activity is unknown.

Name	1-(6,7-bis(difluoromethoxy)naphthalen-2-yl)-2-methyl-1-(1H-1,2,3-triazol-4-yl)propan-1-ol
Synonym	More Synonyms

Description	Seviteronel (VT-464) R enantiomer is the R enantiomer of Seviteronel (VT-464), which is a potent CYP17 lyase inhibitor(h-Lyase IC50=69 nM); Seviteronel (VT-464) R enantiomer's activity is unknown.
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Cancer
References	[1]. Rafferty SW, et al. Highly-selective 4-(1,2,3-triazole)-based P450c17a 17,20-lyase inhibitors. Bioorg Med Chem Lett. 2014 Jun 1;24(11):2444-7. [2]. Sankar N. Maity, et al. Abstract 4772: Efficacy of VT-464, a novel selective inhibitor of cytochrome P450 17,20-lyase, in castrate-resistant prostate cancer models. Cancer Research: April 15, 2013; Volume 73, Issue 8, Supplement 1

Description

Seviteronel (VT-464) R enantiomer is the R enantiomer of Seviteronel (VT-464), which is a potent CYP17 lyase inhibitor(h-Lyase IC50=69 nM); Seviteronel (VT-464) R enantiomer's activity is unknown.

Related Catalog

Signaling Pathways >> Others >> Others

Research Areas >> Cancer

References

[1]. Rafferty SW, et al. Highly-selective 4-(1,2,3-triazole)-based P450c17a 17,20-lyase inhibitors. Bioorg Med Chem Lett. 2014 Jun 1;24(11):2444-7.

[2]. Sankar N. Maity, et al. Abstract 4772: Efficacy of VT-464, a novel selective inhibitor of cytochrome P450 17,20-lyase, in castrate-resistant prostate cancer models. Cancer Research: April 15, 2013; Volume 73, Issue 8, Supplement 1

Molecular Formula	C₁₈H₁₇F₄N₃O₃
Molecular Weight	399.33900
Exact Mass	399.12100
PSA	80.26000
LogP	4.05260
InChIKey	ZBRAJOQFSNYJMF-GOSISDBHSA-N
SMILES	CC(C)C(O)(c1ccc2cc(OC(F)F)c(OC(F)F)cc2c1)c1cn[nH]n1

VT-464 (R enantiomer)

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Shanghai Nianxing Industrial Co., Ltd
China
Product Name: VT-464(Renantiomer)
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Purity: 98.0%
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Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 1-(6,7-bis(difluoromethoxy)naphthalen-2-yl)-2-methyl-1-(1H-1,2,3-triazol-4-yl)propan-1-ol
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Delivery: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

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Price: $462/10mM*1mLinDMSO

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VT-464 (R enantiomer)

Use of VT-464 (R enantiomer)

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VT-464 (R enantiomer) Biological Activity

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The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.