848193-69-1

848193-69-1 structure

Name: EX-527 R-enantiomer
Chemical Name: (1R)-6-Chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide
CAS Number: 848193-69-1
Molecular Formula: C₁₃H₁₃ClN₂O
Molecular Weight: 248.708
Catalog: Research Areas Cancer
Create Date: 2018-05-03 23:01:19
Modify Date: 2024-06-09 22:34:25
Selisistat R-enantiomer (EX-527 R-enantiomer) is much less active R-enantiomer of Selisistat, with an IC50 of > 100 μM for SIRT1.

Name	(1R)-6-Chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide
Synonyms	(1R)-6-Chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide 1H-Carbazole-1-carboxamide, 6-chloro-2,3,4,9-tetrahydro-, (1R)- EX-527 R-enantiomer EX-527 (R-enantiomer)

Description	Selisistat R-enantiomer (EX-527 R-enantiomer) is much less active R-enantiomer of Selisistat, with an IC50 of > 100 μM for SIRT1.
Related Catalog	Research Areas >> Cancer
Target	IC50: > 100 μM (SIRT1)[1]
References	[1]. Napper AD, et al. Discovery of indoles as potent and selective inhibitors of the deacetylase SIRT1. J Med Chem. 2005 Dec 15;48(25):8045-54.