Exaluren

Modify Date: 2023-01-14 12:21:05

Exaluren Structure
Exaluren structure
Common Name Exaluren
CAS Number 1375073-93-0 Molecular Weight 482.53
Density 1.5±0.1 g/cm3 Boiling Point 761.3±60.0 °C at 760 mmHg
Molecular Formula C19H38N4O10 Melting Point N/A
MSDS N/A Flash Point 414.2±32.9 °C

 Use of Exaluren


Exaluren (ELX-02) is an synthetic eukaryotic ribosome-selective glycoside that induces read through of nonsense mutations, resulting in normally localized full-length functional proteins. Exaluren is used for the research of cystic fibrosis caused by nonsense mutations[1].

 Names

Name NB124
Synonym More Synonyms

 Exaluren Biological Activity

Description Exaluren (ELX-02) is an synthetic eukaryotic ribosome-selective glycoside that induces read through of nonsense mutations, resulting in normally localized full-length functional proteins. Exaluren is used for the research of cystic fibrosis caused by nonsense mutations[1].
Related Catalog
References

[1]. Leubitz A, Frydman-Marom A, Sharpe N, van Duzer J, Campbell KCM, Vanhoutte F. Safety, Tolerability, and Pharmacokinetics of Single Ascending Doses of ELX-02, a Potential Treatment for Genetic Disorders Caused by Nonsense Mutations, in Healthy Volunteers. Clin Pharmacol Drug Dev. 2019 Nov;8(8):984-994.

 Chemical & Physical Properties

Density 1.5±0.1 g/cm3
Boiling Point 761.3±60.0 °C at 760 mmHg
Molecular Formula C19H38N4O10
Molecular Weight 482.53
Flash Point 414.2±32.9 °C
Exact Mass 482.258789
LogP -2.28
Vapour Pressure 0.0±5.8 mmHg at 25°C
Index of Refraction 1.640

 Synonyms

D-glycero-α-D-gluco-Heptopyranoside, (1R,2R,3S,4R,6S)-4,6-diamino-2-[(5-amino-5,6-dideoxy-α-L-talofuranosyl)oxy]-3-hydroxycyclohexyl 2-amino-2,7-dideoxy-
NB124
(1R,2R,3S,5R,6S)-3,5-Diamino-2-({(5R)-2-amino-2-deoxy-5-[(1R)-1-hydroxyethyl]-α-D-xylopyranosyl}oxy)-6-hydroxycyclohexyl 5-amino-5,6-dideoxy-α-L-talofuranoside
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