Exaluren

Names

[ Name ]:
Exaluren

[Synonym ]:
D-glycero-α-D-gluco-Heptopyranoside, (1R,2R,3S,4R,6S)-4,6-diamino-2-[(5-amino-5,6-dideoxy-α-L-talofuranosyl)oxy]-3-hydroxycyclohexyl 2-amino-2,7-dideoxy-
NB124
(1R,2R,3S,5R,6S)-3,5-Diamino-2-({(5R)-2-amino-2-deoxy-5-[(1R)-1-hydroxyethyl]-α-D-xylopyranosyl}oxy)-6-hydroxycyclohexyl 5-amino-5,6-dideoxy-α-L-talofuranoside

Biological Activity

[Description]:

Exaluren (ELX-02) is an synthetic eukaryotic ribosome-selective glycoside that induces read through of nonsense mutations, resulting in normally localized full-length functional proteins. Exaluren is used for the research of cystic fibrosis caused by nonsense mutations[1].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Others >> Others

[References]

[1]. Leubitz A, Frydman-Marom A, Sharpe N, van Duzer J, Campbell KCM, Vanhoutte F. Safety, Tolerability, and Pharmacokinetics of Single Ascending Doses of ELX-02, a Potential Treatment for Genetic Disorders Caused by Nonsense Mutations, in Healthy Volunteers. Clin Pharmacol Drug Dev. 2019 Nov;8(8):984-994.

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
761.3±60.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₉H₃₈N₄O₁₀

[ Molecular Weight ]:
482.53

[ Flash Point ]:
414.2±32.9 °C

[ Exact Mass ]:
482.258789

[ LogP ]:
-2.28

[ Vapour Pressure ]:
0.0±5.8 mmHg at 25°C

[ Index of Refraction ]:
1.640

Related Compounds

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.