Nsc-670224
Modify Date: 2024-09-07 17:26:47
Nsc-670224 structure
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Common Name | Nsc-670224 | ||
|---|---|---|---|---|
| CAS Number | 1374648-47-1 | Molecular Weight | 422.86 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C21H34Cl3NO | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of Nsc-670224NSC-670224 is an inhibitor of histone deacetylases-6 (HDAC6) and nuclear factor-κB (NF-κB) activation blocker. It has been shown to be toxic to Saccharomyces cerevisiae at low micromolar concentrations, potentially acts via a mechanism of action related to that of tamoxifen. |
| Name | NSC-670224 |
|---|
| Description | NSC-670224 is an inhibitor of histone deacetylases-6 (HDAC6) and nuclear factor-κB (NF-κB) activation blocker. It has been shown to be toxic to Saccharomyces cerevisiae at low micromolar concentrations, potentially acts via a mechanism of action related to that of tamoxifen. |
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| References | 1. Zuckerman NB, Myers AS, Quan TK, Bray WM, Lokey RS, Hartzog GA, Konopelski JP. Structural determination of NSC 670224, synthesis of analogues and biological evaluation. ChemMedChem. 2012 May;7(5):761-5. doi: 10.1002/cmdc.201200038. Epub 2012 Feb 29. PubMed PMID: 22378491; PubMed Central PMCID: PMC3516922. |
| Molecular Formula | C21H34Cl3NO |
|---|---|
| Molecular Weight | 422.86 |
| InChIKey | FSIBYCVOFLVKGN-UHFFFAOYSA-N |
| SMILES | CN(C)CCOC1(Cc2ccc(Cl)cc2Cl)CCC(C(C)(C)C)CC1.Cl |