Nsc-670224

Names

[ Name ]:
Nsc-670224

Biological Activity

[Description]:

NSC-670224 is an inhibitor of histone deacetylases-6 (HDAC6) and nuclear factor-κB (NF-κB) activation blocker. It has been shown to be toxic to Saccharomyces cerevisiae at low micromolar concentrations, potentially acts via a mechanism of action related to that of tamoxifen.

[References]

1. Zuckerman NB, Myers AS, Quan TK, Bray WM, Lokey RS, Hartzog GA, Konopelski JP. Structural determination of NSC 670224, synthesis of analogues and biological evaluation. ChemMedChem. 2012 May;7(5):761-5. doi: 10.1002/cmdc.201200038. Epub 2012 Feb 29. PubMed PMID: 22378491; PubMed Central PMCID: PMC3516922.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₁H₃₄Cl₃NO

[ Molecular Weight ]:
422.86

Related Compounds

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