Diethyl N-(4-aminobenzoyl)-L-glutamate

Modify Date: 2024-01-02 22:00:25

Diethyl N-(4-aminobenzoyl)-L-glutamate Structure
Diethyl N-(4-aminobenzoyl)-L-glutamate structure
Common Name Diethyl N-(4-aminobenzoyl)-L-glutamate
CAS Number 13726-52-8 Molecular Weight 322.356
Density 1.2±0.1 g/cm3 Boiling Point 522.0±50.0 °C at 760 mmHg
Molecular Formula C16H22N2O5 Melting Point 139-142 °C(lit.)
MSDS Chinese USA Flash Point 269.5±30.1 °C

 Use of Diethyl N-(4-aminobenzoyl)-L-glutamate


N-(4-Aminobenzoyl)-L-glutamic Acid Diethyl Ester is a glutamic acid derivative[1].

 Names

Name diethyl (2S)-2-[(4-aminobenzoyl)amino]pentanedioate
Synonym More Synonyms

 Diethyl N-(4-aminobenzoyl)-L-glutamate Biological Activity

Description N-(4-Aminobenzoyl)-L-glutamic Acid Diethyl Ester is a glutamic acid derivative[1].
Related Catalog
In Vitro Amino acids and amino acid derivatives have been commercially used as ergogenic supplements. They influence the secretion of anabolic hormones, supply of fuel during exercise, mental performance during stress related tasks and prevent exercise induced muscle damage. They are recognized to be beneficial as ergogenic dietary substances[1].
References

[1]. Luckose F, et al. Effects of amino acid derivatives on physical, mental, and physiological activities. Crit Rev Food Sci Nutr. 2015;55(13):1793-1144.

 Chemical & Physical Properties

Density 1.2±0.1 g/cm3
Boiling Point 522.0±50.0 °C at 760 mmHg
Melting Point 139-142 °C(lit.)
Molecular Formula C16H22N2O5
Molecular Weight 322.356
Flash Point 269.5±30.1 °C
Exact Mass 322.152863
PSA 107.72000
LogP 1.79
Vapour Pressure 0.0±1.4 mmHg at 25°C
Index of Refraction 1.536

 MSDS

Name: N-(P-Aminobenzoyl)-L-Glutamic Acid Diethyl Ester 99% Material Safety Data Sheet
Synonym: None Known
CAS: 13726-52-8
Section 1 - Chemical Product MSDS Name:N-(P-Aminobenzoyl)-L-Glutamic Acid Diethyl Ester 99% Material Safety Data Sheet
Synonym:None Known

Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS
CAS# Chemical Name content EINECS#
13726-52-8 N-(P-Aminobenzoyl)-L-Glutamic Acid Die 99% 237-293-1
Hazard Symbols: None Listed.
Risk Phrases: None Listed.

Section 3 - HAZARDS IDENTIFICATION
EMERGENCY OVERVIEW
The toxicological properties of this material have not been fully investigated.
Potential Health Effects
Eye:
May cause eye irritation.
Skin:
May cause skin irritation.
Ingestion:
May cause irritation of the digestive tract. The toxicological properties of this substance have not been fully investigated.
Inhalation:
May cause respiratory tract irritation. The toxicological properties of this substance have not been fully investigated.
Chronic:
No information found.

Section 4 - FIRST AID MEASURES
Eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.
Skin:
Get medical aid. Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.
Ingestion:
Never give anything by mouth to an unconscious person. Get medical aid. Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water.
Inhalation:
Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.
Notes to Physician:

Section 5 - FIRE FIGHTING MEASURES
General Information:
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Runoff from fire control or dilution water may cause pollution.
Extinguishing Media:
Use agent most appropriate to extinguish fire. Use water spray, dry chemical, carbon dioxide, or appropriate foam.

Section 6 - ACCIDENTAL RELEASE MEASURES
General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks:
Vacuum or sweep up material and place into a suitable disposal container. Clean up spills immediately, observing precautions in the Protective Equipment section. Avoid generating dusty conditions.
Provide ventilation.

Section 7 - HANDLING and STORAGE
Handling:
Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Use with adequate ventilation. Minimize dust generation and accumulation. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation.
Storage:
Keep container closed when not in use. Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances.

Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION
Engineering Controls:
Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate ventilation to keep airborne concentrations low.
Exposure Limits CAS# 13726-52-8: Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to prevent skin exposure.
Respirators:
Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced.

Section 9 - PHYSICAL AND CHEMICAL PROPERTIES

Physical State: Powder
Color: off-white
Odor: Not available.
pH: Not available.
Vapor Pressure: Not available.
Viscosity: Not available.
Boiling Point: Not available.
Freezing/Melting Point: 139.00 - 142.00 deg C
Autoignition Temperature: Not applicable.
Flash Point: Not applicable.
Explosion Limits, lower: Not available.
Explosion Limits, upper: Not available.
Decomposition Temperature:
Solubility in water: solubility 2% in ethanol:clear, faint ye
Specific Gravity/Density:
Molecular Formula: C16H22N2O5
Molecular Weight: 322.35

Section 10 - STABILITY AND REACTIVITY
Chemical Stability:
Stable under normal temperatures and pressures.
Conditions to Avoid:
Incompatible materials, dust generation, excess heat, strong oxidants.
Incompatibilities with Other Materials:
Oxidizing agents.
Hazardous Decomposition Products:
Nitrogen oxides, carbon monoxide, irritating and toxic fumes and gases, carbon dioxide, nitrogen.
Hazardous Polymerization: Has not been reported

Section 11 - TOXICOLOGICAL INFORMATION
RTECS#:
CAS# 13726-52-8 unlisted.
LD50/LC50:
Not available.
Carcinogenicity:
N-(P-Aminobenzoyl)-L-Glutamic Acid Diethyl Ester - Not listed by ACGIH, IARC, or NTP.

Section 12 - ECOLOGICAL INFORMATION


Section 13 - DISPOSAL CONSIDERATIONS
Dispose of in a manner consistent with federal, state, and local regulations.

Section 14 - TRANSPORT INFORMATION

IATA
Not regulated as a hazardous material.
IMO
Not regulated as a hazardous material.
RID/ADR
Not regulated as a hazardous material.

Section 15 - REGULATORY INFORMATION

European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: Not available.
Risk Phrases:
Safety Phrases:
S 24/25 Avoid contact with skin and eyes.
WGK (Water Danger/Protection)
CAS# 13726-52-8: No information available.
Canada
None of the chemicals in this product are listed on the DSL/NDSL list.
CAS# 13726-52-8 is not listed on Canada's Ingredient Disclosure List.
US FEDERAL
TSCA
CAS# 13726-52-8 is not listed on the TSCA inventory.
It is for research and development use only.


SECTION 16 - ADDITIONAL INFORMATION
N/A

 Safety Information

Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Safety Phrases S24/25
RIDADR NONH for all modes of transport
WGK Germany 3
HS Code 2924299090

 Synthetic Route

~99%

Diethyl N-(4-aminobenzoyl)-L-glutamate Structure

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CAS#:13726-52-8

Literature: Rahaim Jr., Ronald J.; Maleczka Jr., Robert E. Synthesis, 2006 , # 19 p. 3316 - 3340

~0%

Diethyl N-(4-aminobenzoyl)-L-glutamate Structure

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CAS#:13726-52-8

Literature: Srinivasan, Ananthachari; Amarnath, Venkataraman; Broom, Arthur D.; Zou, F. C.; Cheng, Yung-Chi Journal of Medicinal Chemistry, 1984 , vol. 27, # 12 p. 1710 - 1717

~8%

Diethyl N-(4-aminobenzoyl)-L-glutamate Structure

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CAS#:13726-52-8

Literature: European Journal of Medicinal Chemistry, , vol. 44, # 2 p. 764 - 771

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Diethyl N-(4-aminobenzoyl)-L-glutamate Structure

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CAS#:13726-52-8

Literature: Journal of the American Chemical Society, , vol. 70, p. 20,21,22

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Diethyl N-(4-aminobenzoyl)-L-glutamate Structure

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CAS#:13726-52-8

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Diethyl N-(4-aminobenzoyl)-L-glutamate Structure

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CAS#:13726-52-8

Literature: Journal of the Chemical Society, , p. 1401,1404

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Diethyl N-(4-aminobenzoyl)-L-glutamate Structure

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CAS#:13726-52-8

Literature: Journal of the Chemical Society, , p. 1401,1404

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Diethyl N-(4-aminobenzoyl)-L-glutamate Structure

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CAS#:13726-52-8

Literature: Journal of the Chemical Society, , p. 1401,1404

 Customs

HS Code 2924299090
Summary 2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

 Synonyms

Diethyl N-(p-aminobenzoyl)-L-glutamate
Diethyl N-(4-aminobenzoyl)-L-glutamate
ethyl p-aminobenzoyl-L-glutamate
MFCD00009617
4-Abz-Glu(OEt)-OEt
N-(4-Aminobenzoyl)-L-glutamic Acid Diethyl Ester
L-Glutamic acid, N- (4-aminobenzoyl)-, diethyl ester
L-Glutamic acid, N-(4-aminobenzoyl)-, diethyl ester
N-(p-Aminobenzoyl)-L-glutamic acid diethyl ester
EINECS 237-293-1