RO-7

Modify Date: 2025-08-25 03:42:04

RO-7 Structure
RO-7 structure
Common Name RO-7
CAS Number 1370241-45-4 Molecular Weight 487.49
Density N/A Boiling Point N/A
Molecular Formula C24H20F3N3O3S Melting Point N/A
MSDS N/A Flash Point N/A

 Use of RO-7


RO-7 is a next-generation polymerase (PA) endonuclease inhibitor of influenza A and B viruses.

 Names

Name RO-7

 RO-7 Biological Activity

Description RO-7 is a next-generation polymerase (PA) endonuclease inhibitor of influenza A and B viruses.
Related Catalog
In Vitro RO-7 is a compound that potently inhibits influenza virus replication and belongs to a new class of drugs in late-stage clinical trials for treatment of influenza virus infection. RO-7 displays broad-spectrum anti-influenza activity in vitro and protects mice from lethal challenge with both influenza A and B viruses[1].
In Vivo RO-7 protects mice from lethal challenge with both influenza A and B viruses[1].
References

[1]. Jones JC, et al. Identification of the I38T PA Substitution as a Resistance Marker for Next-Generation InfluenzaVirus Endonuclease Inhibitors. MBio. 2018 Apr 24;9(2). pii: e00430-18.

 Chemical & Physical Properties

Molecular Formula C24H20F3N3O3S
Molecular Weight 487.49
InChIKey XEOTUHPFOHTFEX-VLIAUNLRSA-N
SMILES CC(N1CN(C2c3ccccc3CSc3ccccc32)n2ccc(=O)c(O)c2C1=O)C(F)(F)F
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