RO-7

RO-7 is a next-generation polymerase (PA) endonuclease inhibitor of influenza A and B viruses.

Signaling Pathways >> Anti-infection >> Influenza Virus

Research Areas >> Infection

RO-7 is a compound that potently inhibits influenza virus replication and belongs to a new class of drugs in late-stage clinical trials for treatment of influenza virus infection. RO-7 displays broad-spectrum anti-influenza activity in vitro and protects mice from lethal challenge with both influenza A and B viruses[1].

RO-7 protects mice from lethal challenge with both influenza A and B viruses[1].

[1]. Jones JC, et al. Identification of the I38T PA Substitution as a Resistance Marker for Next-Generation InfluenzaVirus Endonuclease Inhibitors. MBio. 2018 Apr 24;9(2). pii: e00430-18.

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