1-Dehydro-[10]-gingerdione

Modify Date: 2025-08-25 17:49:44

1-Dehydro-[10]-gingerdione Structure
1-Dehydro-[10]-gingerdione structure
 Common Name 1-Dehydro-[10]-gingerdione
CAS Number 136826-50-1 Molecular Weight 346.461
Density 1.1±0.1 g/cm3 Boiling Point 495.2±40.0 °C at 760 mmHg
Molecular Formula C21H30O4 Melting Point N/A
MSDS N/A Flash Point 166.3±20.8 °C

 Use of 1-Dehydro-[10]-gingerdione


1-Dehydro-[10]-gingerdione directly inhibits IKKβ activity by targeting the activation loop of IKKβ, thus disrupting IKKβ-catalysed IκBα phosphorylation in macrophages stimulated with agonists. 1-Dehydro-[10]-gingerdione inhibits LPS-induced NF-κB transcriptional activity. 1-Dehydro-[10]-gingerdione has the potential for NF-κB-associated inflammation and autoimmune disorders research[1].

 Names

Name 1-Dehydro-10-gingerdione
Synonym More Synonyms

 1-Dehydro-[10]-gingerdione Biological Activity

Description 1-Dehydro-[10]-gingerdione directly inhibits IKKβ activity by targeting the activation loop of IKKβ, thus disrupting IKKβ-catalysed IκBα phosphorylation in macrophages stimulated with agonists. 1-Dehydro-[10]-gingerdione inhibits LPS-induced NF-κB transcriptional activity. 1-Dehydro-[10]-gingerdione has the potential for NF-κB-associated inflammation and autoimmune disorders research[1].
Related Catalog
References

[1]. Hwa Young Lee, et al. 1-Dehydro-[10]-gingerdione from ginger inhibits IKKβ activity for NF-κB activation and suppresses NF-κB-regulated expression of inflammatory genes. Br J Pharmacol. 2012 Sep;167(1):128-40.  

 Chemical & Physical Properties

Density 1.1±0.1 g/cm3
Boiling Point 495.2±40.0 °C at 760 mmHg
Molecular Formula C21H30O4
Molecular Weight 346.461
Flash Point 166.3±20.8 °C
Exact Mass 346.214417
LogP 5.51
Vapour Pressure 0.0±1.3 mmHg at 25°C
Index of Refraction 1.531

 Synonyms

1-Tetradecene-3,5-dione, 1-(4-hydroxy-3-methoxyphenyl)-, (1E)-
(1E)-1-(4-Hydroxy-3-methoxyphenyl)-1-tetradecene-3,5-dione
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