1-Dehydro-[10]-gingerdione

Names

[ Name ]:
1-Dehydro-[10]-gingerdione

[Synonym ]:
1-Tetradecene-3,5-dione, 1-(4-hydroxy-3-methoxyphenyl)-, (1E)-
(1E)-1-(4-Hydroxy-3-methoxyphenyl)-1-tetradecene-3,5-dione

Biological Activity

[Description]:

1-Dehydro-[10]-gingerdione directly inhibits IKKβ activity by targeting the activation loop of IKKβ, thus disrupting IKKβ-catalysed IκBα phosphorylation in macrophages stimulated with agonists. 1-Dehydro-[10]-gingerdione inhibits LPS-induced NF-κB transcriptional activity. 1-Dehydro-[10]-gingerdione has the potential for NF-κB-associated inflammation and autoimmune disorders research[1].

[Related Catalog]:

Signaling Pathways >> NF-κB >> IKK

Research Areas >> Inflammation/Immunology

[References]

[1]. Hwa Young Lee, et al. 1-Dehydro-[10]-gingerdione from ginger inhibits IKKβ activity for NF-κB activation and suppresses NF-κB-regulated expression of inflammatory genes. Br J Pharmacol. 2012 Sep;167(1):128-40.

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
495.2±40.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₁H₃₀O₄

[ Molecular Weight ]:
346.461

[ Flash Point ]:
166.3±20.8 °C

[ Exact Mass ]:
346.214417

[ LogP ]:
5.51

[ Vapour Pressure ]:
0.0±1.3 mmHg at 25°C

[ Index of Refraction ]:
1.531

Related Compounds

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