1-Dehydro-6-gingerdione

Modify Date: 2024-01-02 23:35:42

1-Dehydro-6-gingerdione structure	Common Name	1-Dehydro-6-gingerdione
	CAS Number	76060-35-0	Molecular Weight	290.35400
	Density	1.1±0.1 g/cm3	Boiling Point	448.9±40.0 °C at 760 mmHg
	Molecular Formula	C₁₇H₂₂O₄	Melting Point	N/A
	MSDS	N/A	Flash Point	159.3±20.8 °C

Use of 1-Dehydro-6-gingerdione

6-Dehydrogingerdione sensitizes human hepatoblastoma hep G2 cells to TRAIL-induced apoptosis via reactive oxygen species-mediated increase of DR5[1].

Name	1-(4-hydroxy-3-methoxyphenyl)dec-1-ene-3,5-dione
Synonym	More Synonyms

Description	6-Dehydrogingerdione sensitizes human hepatoblastoma hep G2 cells to TRAIL-induced apoptosis via reactive oxygen species-mediated increase of DR5[1].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer
In Vitro	6-Dehydrogingerdione could trigger apoptotic cell death via both mitochondrial- and Fas receptor-mediated pathways[1]. 6-Dehydrogingerdione (6-DG) up-regulates Ser-15 phosphorylation and evoked p53 nuclear translocation[1]. 6-Dehydrogingerdione (6-DG) induces mitochondrial apoptotic pathway[1]. Apoptosis Analysis[1] Cell Line: Hep G2 cells. Concentration: 0, 50, 100 μM. Incubation Time: 24 h. Result: Induced Apoptosis in Hep G2 Cells.
References	[1]. Chung-Yi Chen, et al. 6-dehydrogingerdione sensitizes human hepatoblastoma Hep G2 cells to TRAIL-induced apoptosis via reactive oxygen species-mediated increase of DR5. J Agric Food Chem. 2010 May 12;58(9):5604-11.

Density	1.1±0.1 g/cm3
Boiling Point	448.9±40.0 °C at 760 mmHg
Molecular Formula	C₁₇H₂₂O₄
Molecular Weight	290.35400
Flash Point	159.3±20.8 °C
Exact Mass	290.15200
PSA	63.60000
LogP	3.52260
Vapour Pressure	0.0±1.1 mmHg at 25°C
Index of Refraction	1.546

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Literature: Dennif, Phillip; Macleod, Ian; Whiting, Donald A. Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1981 , p. 82 - 87