Timosaponin BII

Modify Date: 2024-01-02 19:53:32

Timosaponin BII Structure
Timosaponin BII structure
Common Name Timosaponin BII
CAS Number 136656-07-0 Molecular Weight 921.073
Density 1.5±0.1 g/cm3 Boiling Point 1033.6±65.0 °C at 760 mmHg
Molecular Formula C45H76O19 Melting Point N/A
MSDS N/A Flash Point 578.9±34.3 °C

 Use of Timosaponin BII


Timosaponin BII is an antioxidant and an anti-inflammatory agent.

 Names

Name Timosaponin B II
Synonym More Synonyms

 Timosaponin BII Biological Activity

Description Timosaponin BII is an antioxidant and an anti-inflammatory agent.
Related Catalog
In Vitro Timosaponin BII is a steroidal glycoside separated from Zhi Mu, is found to have the inhibitory activity against the proliferation of HL-60 (leukemic), Hela (cervix), HepG2 and Bel-7402 (liver), HT-29 (colon), and MDA-MB-468 (breast) human carcinoma cell lines with an IC50 value of 15.5 μg/mL in the HL-60 cells[1].
In Vivo Rat retinas in model group and vehicle control group manifest an apparent up-regulation of BACE1 expression. Meanwhile, the level of malonaldehyde (MDA), Aβ1-40 and β-CTF are increased. However, when comparing with the vehicle control group, the retinas in Timosaponin-BII treated group showed significantly less BACE1 and accumulated less Aβ1-40 or β-CTF. It also showed significantly decreased level of MDA and prolonged partial thromboplastin time[2].
References

[1]. Guo J, et al. Cytotoxic activities of chemical constituents from rhizomes of Anemarrhena asphodeloides and their analogues. Arch Pharm Res. 2015;38(5):598-603.

[2]. Huang JF, et al. Timosaponin-BII inhibits the up-regulation of BACE1 induced by ferric chloride in rat retina. BMC Complement Altern Med. 2012 Oct 22;12:189.

 Chemical & Physical Properties

Density 1.5±0.1 g/cm3
Boiling Point 1033.6±65.0 °C at 760 mmHg
Molecular Formula C45H76O19
Molecular Weight 921.073
Flash Point 578.9±34.3 °C
Exact Mass 920.498108
PSA 307.37000
LogP 0.34
Vapour Pressure 0.0±0.6 mmHg at 25°C
Index of Refraction 1.627

 Synonyms

(3β,5β,25S)-26-(β-D-Glucopyranosyloxy)-22-hydroxyfurostan-3-yl 2-O-β-D-glucopyranosyl-β-D-galactopyranoside
Timosaponinb-II
β-D-Galactopyranoside, (3β,5β,25S)-26-(β-D-glucopyranosyloxy)-22-hydroxyfurostan-3-yl 2-O-β-D-glucopyranosyl-
N1929
Timosaponin B2
Top Suppliers:I want be here
  • BioBioPha
  • China
  • Product Name: Timosaponin BII
  • Price: ¥Inquiry/20mg
  • Purity: 98.0%
  • Stocking Period: 1 Day
  • Contact: Xueping-Zheng



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Price: ¥1337/10 mM * 1 mL in DMSO

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