ALLO-2

Modify Date: 2025-09-11 14:25:29

ALLO-2 Structure
ALLO-2 structure
Common Name ALLO-2
CAS Number 1357350-60-7 Molecular Weight 371.32
Density N/A Boiling Point N/A
Molecular Formula C18H12F3N5O Melting Point N/A
MSDS N/A Flash Point N/A

 Use of ALLO-2


ALLO-2 is a potent drug-resistant Smoothened (Smo) mutant antagonist that inhibits Smo agonist Hh-Ag1.5-induced luciferase expression in TM3-Gli-Luc cells with IC50 of 6 nM[1].

 Names

Name ALLO-2

 ALLO-2 Biological Activity

Description ALLO-2 is a potent drug-resistant Smoothened (Smo) mutant antagonist that inhibits Smo agonist Hh-Ag1.5-induced luciferase expression in TM3-Gli-Luc cells with IC50 of 6 nM[1].
Related Catalog
Target

IC50: Smo[1].

References

[1]. Tao H, et al. Small molecule antagonists in distinct binding modes inhibit drug-resistant mutant of smoothened. Chem Biol. 2011 Apr 22;18(4):432-7.

 Chemical & Physical Properties

Molecular Formula C18H12F3N5O
Molecular Weight 371.32
InChIKey QTYGEBIJNWMVCW-UHFFFAOYSA-N
SMILES FC(F)(F)Oc1ccc(-c2ccnc(Nc3ccc4[nH]ncc4c3)n2)cc1
Storage condition 2-8℃
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