1357350-60-7

1357350-60-7 structure

Name: ALLO-2
Chemical Name: ALLO-2
CAS Number: 1357350-60-7
Molecular Formula: C₁₈H₁₂F₃N₅O
Molecular Weight: 371.32
Catalog: Signaling Pathways Stem Cell/Wnt Smo
Create Date: 2019-06-01 19:49:51
Modify Date: 2025-09-11 14:25:29
ALLO-2 is a potent drug-resistant Smoothened (Smo) mutant antagonist that inhibits Smo agonist Hh-Ag1.5-induced luciferase expression in TM3-Gli-Luc cells with IC50 of 6 nM[1].

Name	ALLO-2

Description	ALLO-2 is a potent drug-resistant Smoothened (Smo) mutant antagonist that inhibits Smo agonist Hh-Ag1.5-induced luciferase expression in TM3-Gli-Luc cells with IC50 of 6 nM[1].
Related Catalog	Signaling Pathways >> Stem Cell/Wnt >> Smo Research Areas >> Cancer
Target	IC50: Smo[1].
References	[1]. Tao H, et al. Small molecule antagonists in distinct binding modes inhibit drug-resistant mutant of smoothened. Chem Biol. 2011 Apr 22;18(4):432-7.