ALLO-2

Names

[ Name ]:
ALLO-2

Biological Activity

[Description]:

ALLO-2 is a potent drug-resistant Smoothened (Smo) mutant antagonist that inhibits Smo agonist Hh-Ag1.5-induced luciferase expression in TM3-Gli-Luc cells with IC50 of 6 nM[1].

[Related Catalog]:

Signaling Pathways >> Stem Cell/Wnt >> Smo

Research Areas >> Cancer

[Target]

IC50: Smo[1].

[References]

[1]. Tao H, et al. Small molecule antagonists in distinct binding modes inhibit drug-resistant mutant of smoothened. Chem Biol. 2011 Apr 22;18(4):432-7.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₈H₁₂F₃N₅O

[ Molecular Weight ]:
371.32

[ Storage condition ]:
2-8℃

Related Compounds

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