RP-54745
Modify Date: 2025-08-20 12:26:41
RP-54745 structure
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Common Name | RP-54745 | ||
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| CAS Number | 135330-08-4 | Molecular Weight | 297.82300 | |
| Density | 1.46g/cm3 | Boiling Point | 411.4ºC at 760 mmHg | |
| Molecular Formula | C13H12ClNOS2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 202.6ºC | |
Use of RP-54745RP 54745 is an inhibitor of macrophage stimulation and interleukin-1 production, and a potential antirheumatic compound. |
| Name | 4-chloro-5-(1-methyl-3,4-dihydro-1H-isoquinolin-2-yl)dithiol-3-one |
|---|---|
| Synonym | More Synonyms |
| Description | RP 54745 is an inhibitor of macrophage stimulation and interleukin-1 production, and a potential antirheumatic compound. |
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| Related Catalog | |
| In Vitro | RP 54745 diminishes LPS-induced interleukin-1 (IL-1) production by murine peritoneal macrophages[1]. |
| In Vivo | RP 54745 (5 mg/kg) is effective at moderating oral doses in different mouse models of induced arthritis and in the MRL/lpr mice, genetically predisposed to develop an autoimmune pathology including arthritic disorders. The clinical status of the MRL mice, and several of their disturbed biochemical and immunological parameters, improved after a 3-month treatment with RP 54745[2]. |
| References |
| Density | 1.46g/cm3 |
|---|---|
| Boiling Point | 411.4ºC at 760 mmHg |
| Molecular Formula | C13H12ClNOS2 |
| Molecular Weight | 297.82300 |
| Flash Point | 202.6ºC |
| Exact Mass | 297.00500 |
| PSA | 76.79000 |
| LogP | 4.01190 |
| Vapour Pressure | 5.59E-07mmHg at 25°C |
| Index of Refraction | 1.707 |
| Storage condition | 2-8℃ |
| 3H-1,2-Dithiol-3-one,4-chloro-5-(3,4-dihydro-1-methyl-2(1H)-isoquinolinyl) |
| 4-Chloro-5-(3,4-dihydro-1-methyl-2(1H)-isoquinolinyl)-3H-1,2-dithiol-3-one |
| RP-54745 |