221905-35-7
221905-35-7 structure
- Name: Rp-8-CPT-cAMPS sodium
- Chemical Name: Rp-8-CPT-cAMPS sodium
- CAS Number: 221905-35-7
- Molecular Formula: C16H14ClN5NaO5PS2
- Molecular Weight: 509.86
- Catalog: Signaling Pathways Protein Tyrosine Kinase/RTK PKA
- Create Date: 2020-10-18 20:14:23
- Modify Date: 2024-01-13 11:01:45
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Rp-8-CPT-cAMPS sodium, a cAMP analog, is a potent and competitive antagonist of cAMP-induced activation of cAMP-dependent PKA I and II. Rp-8-CPT-cAMPS sodium preferentially selects site A of RI compares to site A of RII and site B of RII compares to site B of RI[1][2].
| Name | Rp-8-CPT-cAMPS sodium |
|---|
| Description | Rp-8-CPT-cAMPS sodium, a cAMP analog, is a potent and competitive antagonist of cAMP-induced activation of cAMP-dependent PKA I and II. Rp-8-CPT-cAMPS sodium preferentially selects site A of RI compares to site A of RII and site B of RII compares to site B of RI[1][2]. |
|---|---|
| Related Catalog | |
| Target |
PKA[1] |
| In Vitro | Rp-8-CPT-cAMPS (100 μM; 15 min) blocks phosphorylation of VASP by 6-Bnz-cAMP and largely reduces VASP phosphorylation by forskolin and fenoterol[2]. Rp-8-CPT-cAMPS (100 μM; 30 min) reduces GTP-loading of Rap1 by both 8-pCPT-2'-O-Me-cAMP and 6-Bnz-cAMP[2]. Rp-8-CPT-cAMPS (100 μM; 30 min) largely diminishes the augmentation of bradykinin-induced IL-8 release by the PKA activator 6-Bnz-cAMP and the Epac activator 8-pCPT-2'-O-Me-cAMP[2]. Rp-8-CPT-cAMPS (10 μM) inhibits the endothelium-dependent and -independent relaxation which induced by Venom in pre-contracted rat mesenteric artery rings[3]. |
| References |
| Molecular Formula | C16H14ClN5NaO5PS2 |
|---|---|
| Molecular Weight | 509.86 |