BACE1-IN-2
Modify Date: 2024-01-11 19:14:39
BACE1-IN-2 structure
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Common Name | BACE1-IN-2 | ||
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| CAS Number | 1352416-78-4 | Molecular Weight | 421.35 | |
| Density | 1.5±0.1 g/cm3 | Boiling Point | N/A | |
| Molecular Formula | C19H15F4N5O2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of BACE1-IN-2BACE1-IN-2 is a 1,4-Oxazine β-Secretase 1 (BACE1) inhibitor with an IC50 of 22 nM[1]. |
| Name | N-{3-[(2R,3R)-5-Amino-3-methyl-2-(trifluoromethyl)-3,6-dihydro-2H-1,4-oxazin-3-yl]-4-fluorophenyl}-5-cyano-2-pyridinecarboxamide |
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| Synonym | More Synonyms |
| Description | BACE1-IN-2 is a 1,4-Oxazine β-Secretase 1 (BACE1) inhibitor with an IC50 of 22 nM[1]. |
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| Related Catalog | |
| Target |
IC50: 22 nM (BACE1)[1] |
| In Vitro | BACE1-IN-2 (Compound 3) is 10-fold more potent toward BACE1 than BACE2, inhibition of which may lead to hair depigmentation. BACE1-IN-2 inhibits hAβ42 cell with an IC50 of 6.0 nM[1]. |
| References |
| Density | 1.5±0.1 g/cm3 |
|---|---|
| Molecular Formula | C19H15F4N5O2 |
| Molecular Weight | 421.35 |
| Exact Mass | 421.116180 |
| LogP | 1.61 |
| Index of Refraction | 1.603 |
| 2-Pyridinecarboxamide, N-[3-[(2R,3R)-5-amino-3,6-dihydro-3-methyl-2-(trifluoromethyl)-2H-1,4-oxazin-3-yl]-4-fluorophenyl]-5-cyano- |
| N-{3-[(2R,3R)-5-Amino-3-methyl-2-(trifluoromethyl)-3,6-dihydro-2H-1,4-oxazin-3-yl]-4-fluorophenyl}-5-cyano-2-pyridinecarboxamide |