LOXO-195 R racemate

Modify Date: 2024-01-08 18:47:15

LOXO-195 R racemate Structure
LOXO-195 R racemate structure
Common Name LOXO-195 R racemate
CAS Number 1350884-56-8 Molecular Weight N/A
Density N/A Boiling Point N/A
Molecular Formula N/A Melting Point N/A
MSDS N/A Flash Point N/A

 Use of LOXO-195 R racemate


(3aR)-Selitrectinib ((3aR)-LOXO-195) is an isform of Selitrectinib (HY-101977), which is a next-generation TRK kinase inhibitor, with IC50s of 0.6 nM and <2.5 nM for TRKA and TRKC, respectively[1].

 Names

Name LOXO-195
Synonym More Synonyms

 LOXO-195 R racemate Biological Activity

Description (3aR)-Selitrectinib ((3aR)-LOXO-195) is an isform of Selitrectinib (HY-101977), which is a next-generation TRK kinase inhibitor, with IC50s of 0.6 nM and <2.5 nM for TRKA and TRKC, respectively[1].
Related Catalog
References

[1]. Drilon A, et al. A Next-Generation TRK Kinase Inhibitor Overcomes Acquired Resistance to Prior TRK Kinase Inhibition in Patients with TRK Fusion-Positive Solid Tumors. Cancer Discov. 2017 Sep;7(9):963-972.  

 Chemical & Physical Properties

No Any Chemical & Physical Properties

 Synonyms

LOXO-195