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1350884-56-8

1350884-56-8 structure
1350884-56-8 structure
  • Name: LOXO-195 R racemate
  • Chemical Name: LOXO-195
  • CAS Number: 1350884-56-8
  • Molecular Formula:
  • Molecular Weight:
  • Catalog: Signaling Pathways Protein Tyrosine Kinase/RTK Trk Receptor
  • Create Date: 2018-06-24 03:42:55
  • Modify Date: 2024-01-08 18:47:15
  • (3aR)-Selitrectinib ((3aR)-LOXO-195) is an isform of Selitrectinib (HY-101977), which is a next-generation TRK kinase inhibitor, with IC50s of 0.6 nM and <2.5 nM for TRKA and TRKC, respectively[1].

Name LOXO-195
Synonyms LOXO-195
Description (3aR)-Selitrectinib ((3aR)-LOXO-195) is an isform of Selitrectinib (HY-101977), which is a next-generation TRK kinase inhibitor, with IC50s of 0.6 nM and <2.5 nM for TRKA and TRKC, respectively[1].
Related Catalog
References

[1]. Drilon A, et al. A Next-Generation TRK Kinase Inhibitor Overcomes Acquired Resistance to Prior TRK Kinase Inhibition in Patients with TRK Fusion-Positive Solid Tumors. Cancer Discov. 2017 Sep;7(9):963-972.  

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