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LOXO-195 R racemate

Names

[ CAS No. ]:
1350884-56-8

[ Name ]:
LOXO-195 R racemate

[Synonym ]:
LOXO-195

Biological Activity

[Description]:

(3aR)-Selitrectinib ((3aR)-LOXO-195) is an isform of Selitrectinib (HY-101977), which is a next-generation TRK kinase inhibitor, with IC50s of 0.6 nM and <2.5 nM for TRKA and TRKC, respectively[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Protein Tyrosine Kinase/RTK >> Trk Receptor

[References]

[1]. Drilon A, et al. A Next-Generation TRK Kinase Inhibitor Overcomes Acquired Resistance to Prior TRK Kinase Inhibition in Patients with TRK Fusion-Positive Solid Tumors. Cancer Discov. 2017 Sep;7(9):963-972.  

Chemical & Physical Properties

No Any Chemical & Physical Properties

Related Compounds