Methapyrilene Hydrochloride structure
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Common Name | Methapyrilene Hydrochloride | ||
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CAS Number | 135-23-9 | Molecular Weight | 297.84700 | |
Density | 1.148g/cm3 | Boiling Point | 389.6ºC at 760 mmHg | |
Molecular Formula | C14H20ClN3S | Melting Point | 162° | |
MSDS | Chinese USA | Flash Point | 189.4ºC | |
Symbol |
GHS06 |
Signal Word | Danger |
Use of Methapyrilene HydrochlorideMethapyrilene (Thenylpyramine) hydrochloride is an orally active H1-receptor antihistamine and an anticholinergic agent of the pyridine chemical class. Methapyrilene hydrochloride has hepatotoxicity and can be used as a hepatotoxin that cause periportal hepatic necrosis in vivo[2] |
Name | methapyrilene hydrochloride |
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Synonym | More Synonyms |
Description | Methapyrilene (Thenylpyramine) hydrochloride is an orally active H1-receptor antihistamine and an anticholinergic agent of the pyridine chemical class. Methapyrilene hydrochloride has hepatotoxicity and can be used as a hepatotoxin that cause periportal hepatic necrosis in vivo[2] |
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Related Catalog | |
Target |
H1 Receptor |
In Vitro | Methapyrilene hydrochloride (650 μM) results in a down-regulation of TF and up-regulation of FTL, while the level of HMOX1 is not changed. Additionally, the levels of CD44 and SOX9 proteins and the expression of PROM1 (CD133), hepatic stem cell-associated markers are increased[1]. Methapyrilene hydrochloride (650 μM) decreases CYP2E1, CYP3A4, NR1l3, ALB, mRNA expression and increases CD133 expression[1]. |
In Vivo | Methapyrilene hydrochloride (oral gavage; 40 or 80 mg/kg; 5 days per week; 6 weeks) results in changes in the expression of classic hepatotoxicity-related marker genes and iron homeostasis-related genes, especially a prominent, dose-dependent down-regulation of the transferrin (Tf) gene and an up-regulation of the ferritin, light chain (FTL) gene in rats[1]. Methapyrilene hydrochloride (oral gavage; 150 mg/kg; 3 days) causes periportal liver necrosis at high dosage. Methapyrilene is sufficient to induce liver necrosis, or a subtoxic dose of 50 mg/kg/day[2]. |
References |
Density | 1.148g/cm3 |
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Boiling Point | 389.6ºC at 760 mmHg |
Melting Point | 162° |
Molecular Formula | C14H20ClN3S |
Molecular Weight | 297.84700 |
Flash Point | 189.4ºC |
Exact Mass | 297.10700 |
PSA | 47.61000 |
LogP | 3.51330 |
Vapour Pressure | 2.82E-06mmHg at 25°C |
Storage condition | room temp |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
MUTATION DATA
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Symbol |
GHS06 |
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Signal Word | Danger |
Hazard Statements | H301 |
Precautionary Statements | P301 + P310 |
Personal Protective Equipment | Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges |
Hazard Codes | T |
Risk Phrases | R25 |
Safety Phrases | S22;S36;S45 |
RIDADR | UN 2811 6.1/PG 3 |
WGK Germany | 3 |
RTECS | UT1750000 |
Packaging Group | III |
Hazard Class | 6.1(b) |
N,N-dimethyl-N'-pyridin-2-yl-N'-(thiophen-2-ylmethyl)ethane-1,2-diamine,hydrochloride |
Methoxylene |
EINECS 205-184-8 |
Methacon |
Lullamin |
Histadyl |
Somnicaps |
Barhist |
Coryzol |
Capathyn |
MFCD00050665 |
METHAPYRILENE HYDROCHLORIDE |
Methapyrilene HCl |