Aminacrine HCl structure
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Common Name | Aminacrine HCl | ||
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CAS Number | 134-50-9 | Molecular Weight | 230.69300 | |
Density | 1.268g/cm3 | Boiling Point | 413.5ºC at 760mmHg | |
Molecular Formula | C13H11ClN2 | Melting Point | N/A | |
MSDS | N/A | Flash Point | 233.2ºC |
Use of Aminacrine HClAminacrine hydrochloride is a highly fluorescent anti-infective dye used clinically as a topical antiseptic and experimentally as a mutagen, due to its interaction with DNA. It is also used as an intracellular pH indicator. |
Name | 9-aminoacridine hydrochloride |
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Synonym | More Synonyms |
Density | 1.268g/cm3 |
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Boiling Point | 413.5ºC at 760mmHg |
Molecular Formula | C13H11ClN2 |
Molecular Weight | 230.69300 |
Flash Point | 233.2ºC |
Exact Mass | 230.06100 |
PSA | 38.91000 |
LogP | 4.35340 |
Vapour Pressure | 4.76E-07mmHg at 25°C |
Synonym:Aminacrine hydrochloride Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS
Risk Phrases: 25 40 Section 3 - HAZARDS IDENTIFICATION EMERGENCY OVERVIEW
Toxic if swallowed. Limited evidence of a carcinogenic effect.The toxicological properties of this material have not been fully investigated.Possible risks of irreversible effects. Potential Health Effects Eye: Causes eye irritation. Skin: May cause skin irritation. Ingestion: Harmful if swallowed. May cause irritation of the digestive tract. The toxicological properties of this substance have not been fully investigated. Inhalation: May cause respiratory tract irritation. The toxicological properties of this substance have not been fully investigated. Chronic: Possible risk of irreversible effects. Section 4 - FIRST AID MEASURES Eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid. Skin: Get medical aid. Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse. Ingestion: Never give anything by mouth to an unconscious person. Get medical aid. Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water. Inhalation: Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid. Notes to Physician: Section 5 - FIRE FIGHTING MEASURES General Information: As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Extinguishing Media: Use agent most appropriate to extinguish fire. Use water spray, dry chemical, carbon dioxide, or appropriate foam. Section 6 - ACCIDENTAL RELEASE MEASURES General Information: Use proper personal protective equipment as indicated in Section 8. Spills/Leaks: Clean up spills immediately, observing precautions in the Protective Equipment section. Sweep up, then place into a suitable container for disposal. Avoid generating dusty conditions. Provide ventilation. Section 7 - HANDLING and STORAGE Handling: Wash thoroughly after handling. Use with adequate ventilation. Minimize dust generation and accumulation. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation. Storage: Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances. Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION Engineering Controls: Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate ventilation to keep airborne concentrations low. Exposure Limits CAS# 134-50-9: CAS# 52417-22-8: Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure. Respirators: A respiratory protection program that meets OSHA's 29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant respirator use. Section 9 - PHYSICAL AND CHEMICAL PROPERTIES Physical State: Powder Color: yellow Odor: None reported. pH: Not available. Vapor Pressure: Not available. Viscosity: Not available. Boiling Point: Not available. Freezing/Melting Point: 300 deg C Autoignition Temperature: Not applicable. Flash Point: Not applicable. Explosion Limits, lower: Not available. Explosion Limits, upper: Not available. Decomposition Temperature: Solubility in water: 0.33g/100 ml water Specific Gravity/Density: >1.0 Molecular Formula: C13H10N2.HCl.H2O Molecular Weight: 248.71 Section 10 - STABILITY AND REACTIVITY Chemical Stability: Stable under normal temperatures and pressures. Conditions to Avoid: Dust generation, excess heat. Incompatibilities with Other Materials: Strong oxidizing agents, strong bases, acid anhydrides. Hazardous Decomposition Products: Hydrogen chloride, nitrogen oxides, carbon monoxide, carbon dioxide. Hazardous Polymerization: Has not been reported. Section 11 - TOXICOLOGICAL INFORMATION RTECS#: CAS# 134-50-9: AR7350000 CAS# 52417-22-8: AR6850000 LD50/LC50: CAS# 134-50-9: Oral, mouse: LD50 = 78 mg/kg. CAS# 52417-22-8. Carcinogenicity: 9-Aminoacridine hydrochloride - Not listed by ACGIH, IARC, or NTP. 9-Aminoacridine hydrochloride monohydrate - Not listed by ACGIH, IARC, or NTP. Other: See actual entry in RTECS for complete information. Section 12 - ECOLOGICAL INFORMATION Section 13 - DISPOSAL CONSIDERATIONS Dispose of in a manner consistent with federal, state, and local regulations. Section 14 - TRANSPORT INFORMATION IATA Shipping Name: TOXIC SOLID, ORGANIC, N.O.S.* Hazard Class: 6.1 UN Number: 2811 Packing Group: III IMO Shipping Name: TOXIC SOLID, ORGANIC, N.O.S. Hazard Class: 6.1 UN Number: 2811 Packing Group: III RID/ADR Shipping Name: TOXIC SOLID, ORGANIC, N.O.S. Hazard Class: 6.1 UN Number: 2811 Packing group: III Section 15 - REGULATORY INFORMATION European/International Regulations European Labeling in Accordance with EC Directives Hazard Symbols: T Risk Phrases: R 25 Toxic if swallowed. R 40 Limited evidence of a carcinogenic effect. Safety Phrases: S 22 Do not breathe dust. S 24/25 Avoid contact with skin and eyes. S 28A After contact with skin, wash immediately with plenty of water. S 37 Wear suitable gloves. S 45 In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible). WGK (Water Danger/Protection) CAS# 134-50-9: No information available. CAS# 52417-22-8: No information available. Canada CAS# 134-50-9 is listed on Canada's NDSL List. CAS# 134-50-9 is not listed on Canada's Ingredient Disclosure List. CAS# 52417-22-8 is not listed on Canada's Ingredient Disclosure List. US FEDERAL TSCA CAS# 134-50-9 is listed on the TSCA inventory. CAS# 52417-22-8 is not on the TSCA Inventory because it is a hydrate. It is considered to be listed if the CAS number for the anhydrous form is on the inventory (40CFR720.3(u)(2)). SECTION 16 - ADDITIONAL INFORMATION N/A |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
MUTATION DATA
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Safety Phrases | 22-24/25 |
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WGK Germany | 3 |
HS Code | 2933990090 |
HS Code | 2933990090 |
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Summary | 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
ACRAMINE YELLOW |
EINECS 205-145-5 |
5-aminoacridinehydrochloride |
Acridin-9-amine hydrochloride |
AMINACRINE HYDROCHLORIDE |
9-aminoacridinium chloride |
9-AMINOACRIDINE HCL |
9-Aminoacridin-hydrochlorid |
aminoacridinehydrochloride |
Aminacrine Hcl |
monacrinhydrochloride |
MONACRIN |