Aristololactam I

Modify Date: 2025-08-21 09:00:26

Aristololactam I Structure
Aristololactam I structure
 Common Name Aristololactam I
CAS Number 13395-02-3 Molecular Weight 293.273
Density 1.5±0.1 g/cm3 Boiling Point 463.9±34.0 °C at 760 mmHg
Molecular Formula C17H11NO4 Melting Point 319 °C
MSDS N/A Flash Point 234.4±25.7 °C

 Use of Aristololactam I


Aristololactam I (AL-I), is the main metabolite of aristolochic acid I (AA-I), participates in the processes that lead to renal damage.Aristololactam I (AL-I) directly injures renal proximal tubule cells, the cytotoxic potency of AL-I is higher than that of AA-I and that the cytotoxic effects of these molecules are mediated through the induction of apoptosis in a caspase-3-dependent pathway[1].

 Names

Name Aristolactam I
Synonym More Synonyms

 Aristololactam I Biological Activity

Description Aristololactam I (AL-I), is the main metabolite of aristolochic acid I (AA-I), participates in the processes that lead to renal damage.Aristololactam I (AL-I) directly injures renal proximal tubule cells, the cytotoxic potency of AL-I is higher than that of AA-I and that the cytotoxic effects of these molecules are mediated through the induction of apoptosis in a caspase-3-dependent pathway[1].
Related Catalog
References

[1]. Li J, et al. Toxicities of aristolochic acid I and aristololactam I in cultured renal epithelial cells. Toxicol In Vitro. 2010 Jun;24(4):1092-7.

 Chemical & Physical Properties

Density 1.5±0.1 g/cm3
Boiling Point 463.9±34.0 °C at 760 mmHg
Melting Point 319 °C
Molecular Formula C17H11NO4
Molecular Weight 293.273
Flash Point 234.4±25.7 °C
Exact Mass 293.068817
PSA 60.55000
LogP 2.97
Vapour Pressure 0.0±1.1 mmHg at 25°C
Index of Refraction 1.763

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
DE5375000
CHEMICAL NAME :
Benzo(f)-1,3-benzodioxolo(6,5,4-cd)indol-5(6H)-one, 8-methoxy-
CAS REGISTRY NUMBER :
13395-02-3
BEILSTEIN REFERENCE NO. :
0307971
LAST UPDATED :
199612
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C17-H11-N-O4
MOLECULAR WEIGHT :
293.29

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :
Mutation in microorganisms
TEST SYSTEM :
Bacteria - Salmonella typhimurium
DOSE/DURATION :
50 ug/plate
REFERENCE :
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980- Volume(issue)/page/year: 7,59,1986

 Safety Information

Hazard Codes Xi
RIDADR UN 2811
Packaging Group III
Hazard Class 6.1(b)
HS Code 2933990090

 Synthetic Route

Aristolochic acid A structure

Aristolochic acid A

CAS#:313-67-7

~%

Aristololactam I Structure

Aristololactam I

CAS#:13395-02-3

Literature: Archiv der Pharmazie, , vol. 320, # 3 p. 264 - 270
Aristolochic acid A structure

Aristolochic acid A

CAS#:313-67-7

acetic acid structure

acetic acid

CAS#:64-19-7

~%

N/A structure

N/A

CAS#:1260173-11-2

Aristololactam I Structure

Aristololactam I

CAS#:13395-02-3

Literature: Journal of Natural Products, , vol. 73, # 12 p. 1979 - 1986

 Customs

HS Code 2933990090
Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Synonyms

1,3-Benzodioxolo[6,5,4-cd]benz[f]indol-5(6H)-one, 8-methoxy-
Aristololactam
8-Methoxy[1,3]benzodioxolo[6,5,4-cd]benzo[f]indol-5(6H)-one
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