YL-0919
Modify Date: 2024-01-02 19:29:44
YL-0919 structure
|
Common Name | YL-0919 | ||
|---|---|---|---|---|
| CAS Number | 1339058-04-6 | Molecular Weight | 334.84 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C18H23ClN2O2 | Melting Point | 216 - 218 °C | |
| MSDS | N/A | Flash Point | N/A | |
Use of YL-0919YL0919, a novel antidepressant candidate with dual activity as a 5-HT1A receptor agonist and a selective serotonin reuptake inhibitor,the IC50 values of YL-0919 inhibiting the uptake of 5-HT into rat cerebral cortical synaptosomes and human recombinant cells were 1.78±0.34 nM and 1.93±0.18 nM respectively.target: 5-HT1A receptorIC50:1.78±0.34 nM(rat cerebral cortical synaptosomes)IC50:1.93±0.18 nM(human recombinant cells)[1]"In vivo: WAY-100635 completely antagonized the antidepressant-like activity of YL-0919 in both behavioral models, suggesting that activation of the 5-HT1A receptor is critical in the antidepressant-like effect of YL-0919. The administered dose of WAY-100635 ranged from 0.1–0.3 mg/kg, which reportedly has no effect on locomotor activity and only blocks the activation of 5-HT1A receptor.[2] |
| Name | YL 0919 |
|---|---|
| Synonym | More Synonyms |
| Description | YL0919, a novel antidepressant candidate with dual activity as a 5-HT1A receptor agonist and a selective serotonin reuptake inhibitor,the IC50 values of YL-0919 inhibiting the uptake of 5-HT into rat cerebral cortical synaptosomes and human recombinant cells were 1.78±0.34 nM and 1.93±0.18 nM respectively.target: 5-HT1A receptorIC50:1.78±0.34 nM(rat cerebral cortical synaptosomes)IC50:1.93±0.18 nM(human recombinant cells)[1]"In vivo: WAY-100635 completely antagonized the antidepressant-like activity of YL-0919 in both behavioral models, suggesting that activation of the 5-HT1A receptor is critical in the antidepressant-like effect of YL-0919. The administered dose of WAY-100635 ranged from 0.1–0.3 mg/kg, which reportedly has no effect on locomotor activity and only blocks the activation of 5-HT1A receptor.[2] |
|---|---|
| Related Catalog | |
| References |
| Melting Point | 216 - 218 °C |
|---|---|
| Molecular Formula | C18H23ClN2O2 |
| Molecular Weight | 334.84 |
| Appearance of Characters | colourless |
| Storage condition | 2-8℃ |
| 1-[(1-benzyl-4-hydroxypiperidin-4-yl)-methyl]-pyridin-2(1H)-one hydrochloride |
| YL-0919 |
| YL0919 |