MPT0E028
Modify Date: 2025-08-23 19:55:27
MPT0E028 structure
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Common Name | MPT0E028 | ||
|---|---|---|---|---|
| CAS Number | 1338320-94-7 | Molecular Weight | 344.38500 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C17H16N2O4S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of MPT0E028MPT0E028 is an orally active and selective HDAC inhibitor with IC50s of 53.0 nM, 106.2 nM, 29.5 nM for HDAC1, HDAC2 and HDAC6, respectively[1]. MPT0E028 reduces the viability of B-cell lymphomas by inducing apoptosis and possesses potent direct Akt targeting ability and reduces Akt phosphorylation in B-cell lymphoma. MPT0E028 has good anticancer activity[2]. |
| Name | (E)-3-[1-(benzenesulfonyl)-2,3-dihydroindol-5-yl]-N-hydroxyprop-2-enamide |
|---|---|
| Synonym | More Synonyms |
| Description | MPT0E028 is an orally active and selective HDAC inhibitor with IC50s of 53.0 nM, 106.2 nM, 29.5 nM for HDAC1, HDAC2 and HDAC6, respectively[1]. MPT0E028 reduces the viability of B-cell lymphomas by inducing apoptosis and possesses potent direct Akt targeting ability and reduces Akt phosphorylation in B-cell lymphoma. MPT0E028 has good anticancer activity[2]. |
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| Related Catalog | |
| Target |
HDAC1:53.0 nM (IC50) HDAC2:106.2 nM (IC50) HDAC6:29.5 nM (IC50) HDAC8:2532.6 nM (IC50) Akt |
| References |
| Molecular Formula | C17H16N2O4S |
|---|---|
| Molecular Weight | 344.38500 |
| Exact Mass | 344.08300 |
| PSA | 98.58000 |
| LogP | 3.94270 |
| 3-(1-(Benzenesulfonyl)-2,3-dihydro-1H-indol-5-yl)-N-hydroxyacrylamide |
| 2-Propenamide,3-(2,3-dihydro-1-(phenylsulfonyl)-1H-indol-5-yl)-N-hydroxy |
| UNII-T65L58FI65 |