(E/Z)-Locostatin
Modify Date: 2025-08-25 15:15:56
(E/Z)-Locostatin structure
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Common Name | (E/Z)-Locostatin | ||
|---|---|---|---|---|
| CAS Number | 133812-16-5 | Molecular Weight | 245.27400 | |
| Density | 1.205g/cm3 | Boiling Point | 351ºC at 760mmHg | |
| Molecular Formula | C14H15NO3 | Melting Point | 84-88ºC(lit.) | |
| MSDS | N/A | Flash Point | 166.1ºC | |
Use of (E/Z)-Locostatin(E/Z)-Locostatin ((E/Z)-UIC-1005) is a racemic of Locostatin. Locostatin (UIC-1005) is a potent RKIP inhibitor. Locostatin binds Raf kinase inhibitor RKIP protein and disrupts the interaction of RKIP with Raf-1 kinase and G protein-coupled receptor kinase 2. Locostatin inhibits cell proliferation and migration. Locostatin aggravates thioacetamide (HY-Y0698)-induced acute liver failure in mice [1][2][3]. |
| Name | (S)-4-Benzyl-3-(but-2-enoyl)oxazolidin-2-one |
|---|---|
| Synonym | More Synonyms |
| Description | (E/Z)-Locostatin ((E/Z)-UIC-1005) is a racemic of Locostatin. Locostatin (UIC-1005) is a potent RKIP inhibitor. Locostatin binds Raf kinase inhibitor RKIP protein and disrupts the interaction of RKIP with Raf-1 kinase and G protein-coupled receptor kinase 2. Locostatin inhibits cell proliferation and migration. Locostatin aggravates thioacetamide (HY-Y0698)-induced acute liver failure in mice [1][2][3]. |
|---|---|
| Related Catalog | |
| Target |
RKIP[3] |
| References |
| Density | 1.205g/cm3 |
|---|---|
| Boiling Point | 351ºC at 760mmHg |
| Melting Point | 84-88ºC(lit.) |
| Molecular Formula | C14H15NO3 |
| Molecular Weight | 245.27400 |
| Flash Point | 166.1ºC |
| Exact Mass | 245.10500 |
| PSA | 46.61000 |
| LogP | 2.09050 |
| Vapour Pressure | 4.22E-05mmHg at 25°C |
| Index of Refraction | 1.57 |
| Hazard Codes | Xn |
|---|
| MFCD00278769 |