N-Pyrazinylcarbonylphenylalanine-d8

Modify Date: 2024-04-03 21:28:04

N-Pyrazinylcarbonylphenylalanine-d8 Structure
N-Pyrazinylcarbonylphenylalanine-d8 structure
Common Name N-Pyrazinylcarbonylphenylalanine-d8
CAS Number 1331912-47-0 Molecular Weight 279.32
Density N/A Boiling Point N/A
Molecular Formula C14H5D8N3O3 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of N-Pyrazinylcarbonylphenylalanine-d8


N-Pyrazinylcarbonylphenylalanine-d8 is the deuterium labeled Deruxtecan. Deruxtecan is an ADC drug-linker conjugate composed of a derivative of DX-8951 (DXd) and amaleimide-GGFG peptide linker, used for synthesizing DS-8201 and U3-1402.

 Names

Name N-Pyrazinylcarbonylphenylalanine-d8

 N-Pyrazinylcarbonylphenylalanine-d8 Biological Activity

Description N-Pyrazinylcarbonylphenylalanine-d8 is the deuterium labeled Deruxtecan. Deruxtecan is an ADC drug-linker conjugate composed of a derivative of DX-8951 (DXd) and amaleimide-GGFG peptide linker, used for synthesizing DS-8201 and U3-1402.
Related Catalog
In Vitro Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[75].
References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-223.

 Chemical & Physical Properties

Molecular Formula C14H5D8N3O3
Molecular Weight 279.32