5-HT6/7 antagonist 1

Modify Date: 2025-08-25 17:51:20

5-HT6/7 antagonist 1 Structure
5-HT6/7 antagonist 1 structure
Common Name 5-HT6/7 antagonist 1
CAS Number 131999-28-5 Molecular Weight 393.41
Density N/A Boiling Point N/A
Molecular Formula C22H20FN3O3 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of 5-HT6/7 antagonist 1


5-HT6/7 antagonist 1 is a multifunctional ligand that antagonizes 5-HT6/7/2A and D2 receptors, without interacting with M1 receptors and hERG channels.

 Names

Name 5-HT6/7 antagonist 1

 5-HT6/7 antagonist 1 Biological Activity

Description 5-HT6/7 antagonist 1 is a multifunctional ligand that antagonizes 5-HT6/7/2A and D2 receptors, without interacting with M1 receptors and hERG channels.
Related Catalog
Target

5-HT6/7/2A, D2[1]

In Vitro Targeting 5-HT6 and/ or 5-HT7 receptors with antagonist drugs could constitute a promising strategy for treating symptoms of BPSD while avoiding some of the side effects of current antipsychotic drugs. Nevertheless, due to the complex pathology of dementia and accompanying behavioral and psychological symptoms, it seems unlikely that focusing on a single therapeutic target would be sufficient to provide adequate clinical benefit, and it is likely that successful development of novel anti-BPSD agents should involve a “designed” multifactorial approach[1].
References

[1]. Kołaczkowski M, et al. Novel arylsulfonamide derivatives with 5-HT₆/5-HT₇ receptor antagonism targeting behavioral and psychological symptoms of dementia. J Med Chem. 2014 Jun 12;57(11):4543-57.

 Chemical & Physical Properties

Molecular Formula C22H20FN3O3
Molecular Weight 393.41
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