Villocarine A

Modify Date: 2025-08-27 09:20:46

Villocarine A structure	Common Name	Villocarine A
	CAS Number	1319743-81-1	Molecular Weight	366.45
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₂H₂₆N₂O₃	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Villocarine A

Villocarine A is a natural vasorelaxant indole alkaloid[1].

Name	Indolo[2,3-a]quinolizine-2-acetic acid, 3-ethylidene-1,2,3,4,6,7,12,12b-octahydro-α-(methoxymethylene)-, methyl ester, (αE,2S,3E,12bR)-

Description	Villocarine A is a natural vasorelaxant indole alkaloid[1].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Metabolic Disease
In Vitro	Villocarine A exhibited excellent activity during the initial stage, within 10-30 min after injection, with potent vasorelaxant effects observed at 30 μM against PE-mediated contraction in a rat aorta. Villocarine A exhibited a moderate level of inhibition at 30 μM against PE and 1 μM-induced contraction of the aortic rings in the presence of nicardipine (1 μM) in a Ca2+-free medium[2].
References	[1]. Hirotaka Matsuo, et al. New vasorelaxant indole alkaloids, villocarines A-D from Uncaria villosa. Bioorg Med Chem. 2011 Jul 1;19(13):4075-9. [2]. Faisal Omar, et al. Plant-Based Indole Alkaloids: A Comprehensive Overview from a Pharmacological Perspective. Molecules. 2021 Apr 15;26(8):2297.

Molecular Formula	C₂₂H₂₆N₂O₃
Molecular Weight	366.45
InChIKey	VAMJZLUOKJRHOW-YNIQLQCKSA-N
SMILES	CC=C1CN2CCc3c([nH]c4ccccc34)C2CC1C(=COC)C(=O)OC

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Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Villocarine A
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