Villocarine A

Names

[ CAS No. ]:
1319743-81-1

[ Name ]:
Villocarine A

Biological Activity

[Description]:

Villocarine A is a natural vasorelaxant indole alkaloid[1].

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Metabolic Disease

[In Vitro]

Villocarine A exhibited excellent activity during the initial stage, within 10-30 min after injection, with potent vasorelaxant effects observed at 30 μM against PE-mediated contraction in a rat aorta. Villocarine A exhibited a moderate level of inhibition at 30 μM against PE and 1 μM-induced contraction of the aortic rings in the presence of nicardipine (1 μM) in a Ca2+-free medium[2].

[References]

[1]. Hirotaka Matsuo, et al. New vasorelaxant indole alkaloids, villocarines A-D from Uncaria villosa. Bioorg Med Chem. 2011 Jul 1;19(13):4075-9.

[2]. Faisal Omar, et al. Plant-Based Indole Alkaloids: A Comprehensive Overview from a Pharmacological Perspective. Molecules. 2021 Apr 15;26(8):2297.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₂H₂₆N₂O₃

[ Molecular Weight ]:
366.45

Related Compounds

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