Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Villocarine A
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Purity: 98.0%
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1319743-81-1

1319743-81-1 structure

1319743-81-1 structure

Name: Villocarine A
Chemical Name: Indolo[2,3-a]quinolizine-2-acetic acid, 3-ethylidene-1,2,3,4,6,7,12,12b-octahydro-α-(methoxymethylene)-, methyl ester, (αE,2S,3E,12bR)-
CAS Number: 1319743-81-1
Molecular Formula: C₂₂H₂₆N₂O₃
Molecular Weight: 366.45
Catalog: Research Areas Metabolic Disease
Create Date: 2023-08-21 17:24:14
Modify Date: 2025-08-27 09:20:46
Villocarine A is a natural vasorelaxant indole alkaloid[1].

Name	Indolo[2,3-a]quinolizine-2-acetic acid, 3-ethylidene-1,2,3,4,6,7,12,12b-octahydro-α-(methoxymethylene)-, methyl ester, (αE,2S,3E,12bR)-

Description	Villocarine A is a natural vasorelaxant indole alkaloid[1].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Metabolic Disease
In Vitro	Villocarine A exhibited excellent activity during the initial stage, within 10-30 min after injection, with potent vasorelaxant effects observed at 30 μM against PE-mediated contraction in a rat aorta. Villocarine A exhibited a moderate level of inhibition at 30 μM against PE and 1 μM-induced contraction of the aortic rings in the presence of nicardipine (1 μM) in a Ca2+-free medium[2].
References	[1]. Hirotaka Matsuo, et al. New vasorelaxant indole alkaloids, villocarines A-D from Uncaria villosa. Bioorg Med Chem. 2011 Jul 1;19(13):4075-9. [2]. Faisal Omar, et al. Plant-Based Indole Alkaloids: A Comprehensive Overview from a Pharmacological Perspective. Molecules. 2021 Apr 15;26(8):2297.

Molecular Formula	C₂₂H₂₆N₂O₃
Molecular Weight	366.45

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