Arbidol

Modify Date: 2024-01-02 22:32:15

Arbidol structure	Common Name	Arbidol
	CAS Number	131707-25-0	Molecular Weight	477.41
	Density	1.4±0.1 g/cm3	Boiling Point	591.8±50.0 °C at 760 mmHg
	Molecular Formula	C₂₂H₂₅BrN₂O₃S	Melting Point	N/A
	MSDS	N/A	Flash Point	311.7±30.1 °C

Use of Arbidol

Umifenovir is a potent, orally active broad-spectrum antiviral agent with activity against a number of enveloped and non-enveloped viruses. Umifenovir is used as an anti-influenza virus agent. Umifenovir could effectively inhibit the fusion of virus with host cells[1][2]. Umifenovir is an efficient inhibitor of SARS-CoV-2 in vitro[2]. Umifenovir shows anti-inflammatory activity[3].

Name	ethyl 6-bromo-4-[(dimethylamino)methyl]-5-hydroxy-1-methyl-2-(phenylsulfanylmethyl)indole-3-carboxylate
Synonym	More Synonyms

Description	Umifenovir is a potent, orally active broad-spectrum antiviral agent with activity against a number of enveloped and non-enveloped viruses. Umifenovir is used as an anti-influenza virus agent. Umifenovir could effectively inhibit the fusion of virus with host cells[1][2]. Umifenovir is an efficient inhibitor of SARS-CoV-2 in vitro[2]. Umifenovir shows anti-inflammatory activity[3].
Related Catalog	Signaling Pathways >> Anti-infection >> Influenza Virus Research Areas >> Infection Signaling Pathways >> Anti-infection >> SARS-CoV
In Vitro	Umifenovir exhibits a wide range and potent antiviral activity against a number of viruses including influenza viruses A, B and C, respiratory syncytial virus, SARS-CoV, adenovirus, parainfluenza type 5, poliovirus 1, rhinovirus 14, coxsackievirus B5, hantaan virus, Chikungunya virus, HBV and HCV[1].
In Vivo	Umifenovir (25 and 45 mg/ml; p.o.;) shows a survival benefit to mice suffering from influenza infection[3]. Animal Model: BALB/c mice (6–8 weeks old), mice were intranasally (i.n.) inoculated with 2 times the 50% mouse lethal dose (MLD50) of A/ Guangdong/GIRD07/09 (H1N1) (104.5TCID50/mL) in a volume of 20mL[3]. Dosage: 1.25 mg/mL (25 mg/kg/day) and 2.25 mg/mL (45 mg/kg/day) in a total volume of 500mL at one day pre-infection and 3 days post-infection (dpi) Administration: Oral administration Result: Increased the survival rate, inhibited the decrease of body weight at 45 mg/mL and inhibited the increase of mice lung index at 25 mg/mL and 45 mg/mL comparing to virus group.
References	[1]. Julie Blaising, et al. Arbidol as a broad-spectrum antiviral: an update. Antiviral Res. 2014 Jul;107:84-94. doi: 10.1016/j.antiviral.2014.04.006. Epub 2014 Apr 24. [2]. Irina Leneva, et al. Antiviral Activity of Umifenovir In Vitro against a Broad Spectrum of Coronaviruses, Including the Novel SARS-CoV-2 Virus. Viruses. 2021 Aug 23;13(8):1665. [3]. Yutao Wang, et al. Inhibition of the infectivity and inflammatory response of influenza virus by Arbidol hydrochloride in vitro and in vivo (mice and ferret). Biomed Pharmacother. 2017 Jul;91:393-401.

Density	1.4±0.1 g/cm3
Boiling Point	591.8±50.0 °C at 760 mmHg
Molecular Formula	C₂₂H₂₅BrN₂O₃S
Molecular Weight	477.41
Flash Point	311.7±30.1 °C
Exact Mass	476.076904
PSA	80.00000
LogP	4.64
Vapour Pressure	0.0±1.7 mmHg at 25°C
Index of Refraction	1.620

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Ethyl 6-bromo-5...

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~86%

Arbidol

CAS#:131707-25-0

Literature: Pharmaceutical Chemistry Journal, , vol. 27, # 1 p. 75 - 76 Khimiko-Farmatsevticheskii Zhurnal, , vol. 27, # 1 p. 70 - 71

Formaldehyde

CAS#:50-00-0

Ethyl 6-bromo-5...

CAS#:131707-24-9

Arbidol

CAS#:131707-25-0

Literature: US5198552 A1, ;

Bis(dimethylami...

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Ethyl 6-bromo-5...

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~71%

Arbidol

CAS#:131707-25-0

Literature: Pharmaceutical Chemistry Journal, , vol. 27, # 1 p. 75 - 76 Khimiko-Farmatsevticheskii Zhurnal, , vol. 27, # 1 p. 70 - 71

ethyl5-acetoxy-...

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Arbidol

CAS#:131707-25-0

Literature: Pharmaceutical Chemistry Journal, , vol. 27, # 1 p. 75 - 76 Khimiko-Farmatsevticheskii Zhurnal, , vol. 27, # 1 p. 70 - 71

Ethyl 5-(acetyl...

CAS#:40945-79-7

Arbidol

CAS#:131707-25-0

Literature: Pharmaceutical Chemistry Journal, , vol. 27, # 1 p. 75 - 76 Khimiko-Farmatsevticheskii Zhurnal, , vol. 27, # 1 p. 70 - 71

1H-Indole-3-carboxylic acid, 6-bromo-4-[(dimethylamino)methyl]-5-hydroxy-1-methyl-2-[(phenylthio)methyl]-, ethyl ester

1-methyl-2-phenylthiomethyl-3-ethoxycarbonyl-4-dimethylaminomethyl-5-hydroxy-6-bromindole

ethyl 6-bromo-5-hydroxy-4-dimethylaminomethyl-1-methyl-2-phenylthiomethylindole-3-carboxylate

Ethyl 6-bromo-4-[(dimethylamino)methyl]-5-hydroxy-1-methyl-2-[(phenylsulfanyl)methyl]-1H-indole-3-carboxylate

Umifenovir

6-bromo-5-hydroxy-4-dimethylaminomethyl-1-methyl-2-phenylthiomethylindole-3-carboxylic acid ethyl ester

6-bromo-4-dimethylaminomethyl-3-ethoxycarbonyl-5-hydroxy-1-methyl-2-phenylthiomethylindole

Arbidol

1-methyl-2-phenylthiomethyl-3-carbethoxy-4-dimethylaminomethyl-5-oxy-6-bromoindole

HMS589B06

DC Chemicals Limited
China
Product Name: Umifenovir
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Zhejiang Hangyu API Co., Ltd
China
Product Name: Arbidol
Price: ￥Inquiry/1kg
Purity: 99.5%
Stocking Period: Inquiry
Contact: Vinnie

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Arbidol

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