Promestriene-d3

Modify Date: 2024-04-06 18:20:50

Promestriene-d3 structure	Common Name	Promestriene-d3
	CAS Number	1316849-37-2	Molecular Weight	331.51
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₂H₂₉D₃O₂	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Promestriene-d3

Promestriene-d3 is the deuterium labeled Promestriene. Promestriene is a synthetic diethyl-ether of estradiol and a locally effective estrogen. Promestriene has an efficient action on vaginal atrophy while it is minimally absorbed[1][2].

Name	Promestriene-d3

Description	Promestriene-d3 is the deuterium labeled Promestriene. Promestriene is a synthetic diethyl-ether of estradiol and a locally effective estrogen. Promestriene has an efficient action on vaginal atrophy while it is minimally absorbed[1][2].
Related Catalog	Research Areas >> Cancer Research Areas >> Endocrinology Signaling Pathways >> Others >> Others
In Vitro	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [2]. Isabel Santos, et al. Urogenital Disorders Associated With Oestrogen Deficiency: The Role of Promestriene as Topical Oestrogen Therapy. Gynecol Endocrinol. 2010 Sep;26(9):644-51. [3]. Lino Del Pup, et al. Promestriene, a Specific Topic Estrogen. Review of 40 Years of Vaginal Atrophy Treatment: Is It Safe Even in Cancer Patients. Anticancer Drugs. 2013 Nov;24(10):989-98. [4]. AJO Almodovar, et al. Abstract P5-05-07: Promestriene effects on estrogen-sensitive breast cancer cell proliferation in vitro. Cancer Res 2013;73(24 Suppl): Abstract nr P5-05-07.

Molecular Formula	C₂₂H₂₉D₃O₂
Molecular Weight	331.51

Promestriene-d3

Use of Promestriene-d3

Names

Promestriene-d3 Biological Activity

Chemical & Physical Properties