39219-28-8

39219-28-8 structure

Name: Promestriene
Chemical Name: Promestriene
CAS Number: 39219-28-8
Molecular Formula: C₂₂H₃₂O₂
Molecular Weight: 328.488
Catalog: API Hormone and endocrine-regulating drugs Estrogen and progestogen drugs
Create Date: 2018-08-14 11:54:18
Modify Date: 2025-08-20 13:52:32
Promestriene is a synthetic diethyl-ether of estradiol and a locally effective estrogen. Promestriene has an efficient action on vaginal atrophy while it is minimally absorbed[1][2].

Name	Promestriene
Synonyms	17-Methoxy-3-propoxyestra-1,3,5(10)-triene MFCD00867247 Promestriene EINECS 254-361-6 Promestriene [DCF:INN] Estra-1,3,5(10)-triene, 17-methoxy-3-propoxy- 3-Propoxy-17beta-methoxy-1,3,5(10)-estratriene

Description	Promestriene is a synthetic diethyl-ether of estradiol and a locally effective estrogen. Promestriene has an efficient action on vaginal atrophy while it is minimally absorbed[1][2].
Related Catalog	Research Areas >> Cancer Research Areas >> Endocrinology Signaling Pathways >> Others >> Others
In Vitro	Promestriene is an analogue of oestradiol which is minimally absorbed and devoid of systemic effects when administered intravaginally, either as gynecological cream or capsules[2]. Topical Promestriene is minimally absorbed with chronic use and has been reported to significantly improve the symptoms of vaginal atrophy[3].
References	[1]. Isabel Santos, et al. Urogenital Disorders Associated With Oestrogen Deficiency: The Role of Promestriene as Topical Oestrogen Therapy. Gynecol Endocrinol. 2010 Sep;26(9):644-51. [2]. Lino Del Pup, et al. Promestriene, a Specific Topic Estrogen. Review of 40 Years of Vaginal Atrophy Treatment: Is It Safe Even in Cancer Patients. Anticancer Drugs. 2013 Nov;24(10):989-98. [3]. AJO Almodovar, et al. Abstract P5-05-07: Promestriene effects on estrogen-sensitive breast cancer cell proliferation in vitro. Cancer Res 2013;73(24 Suppl): Abstract nr P5-05-07.