RP101442

Modify Date: 2025-08-27 12:25:36

RP101442 Structure
RP101442 structure
Common Name RP101442
CAS Number 1306761-08-9 Molecular Weight 402.45
Density N/A Boiling Point N/A
Molecular Formula C23H22N4O3 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of RP101442


RP101442, an active metabolite of Ozanimod, is a selective, potent S1PR1 (sphingosine-1-phosphate receptor 1) agonist, with EC50s of 2.6 nM and 171 nM for S1PR1 and S1PR5, respectively[1].

 Names

Name RP101442

 RP101442 Biological Activity

Description RP101442, an active metabolite of Ozanimod, is a selective, potent S1PR1 (sphingosine-1-phosphate receptor 1) agonist, with EC50s of 2.6 nM and 171 nM for S1PR1 and S1PR5, respectively[1].
Related Catalog
Target

S1PR1:2.6 nM (EC50)

S1PR5:171 nM (EC50)

References

[1]. Tran JQ, et al. Cardiac Safety of Ozanimod, a Novel Sphingosine-1-Phosphate Receptor Modulator: Results of a Thorough QT/QTc Study. Clin Pharmacol Drug Dev. 2018;7(3):263-276.

 Chemical & Physical Properties

Molecular Formula C23H22N4O3
Molecular Weight 402.45
InChIKey FVWMDPLFGXHGCN-FQEVSTJZSA-N
SMILES CC(=O)NC1CCc2c(-c3noc(-c4ccc(OC(C)C)c(C#N)c4)n3)cccc21
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