RP101442

Names

[ Name ]:
RP101442

Biological Activity

[Description]:

RP101442, an active metabolite of Ozanimod, is a selective, potent S1PR1 (sphingosine-1-phosphate receptor 1) agonist, with EC50s of 2.6 nM and 171 nM for S1PR1 and S1PR5, respectively[1].

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> LPL Receptor

Research Areas >> Inflammation/Immunology

[Target]

S1PR1:2.6 nM (EC50)

S1PR5:171 nM (EC50)

[References]

[1]. Tran JQ, et al. Cardiac Safety of Ozanimod, a Novel Sphingosine-1-Phosphate Receptor Modulator: Results of a Thorough QT/QTc Study. Clin Pharmacol Drug Dev. 2018;7(3):263-276.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₃H₂₂N₄O₃

[ Molecular Weight ]:
402.45

Related Compounds

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