ORM-15341
Modify Date: 2025-08-25 14:07:33
ORM-15341 structure
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Common Name | ORM-15341 | ||
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| CAS Number | 1297537-33-7 | Molecular Weight | 396.83000 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C19H17ClN6O2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of ORM-15341ORM-15341 is a potent and full antagonist for human AR (hAR) with IC50 values of 38 nM as shown by transactivation assays in AR-HEK293 cells stably expressing full-length hAR and an androgen-responsive luciferase reporter gene construct.IC50 value: 38 nMTarget: androgen receptorin vitro: In competitive AR binding assays, the inhibition constant (Ki) values of ORM-15341 was 8 nM. ORM-15341 functions as a full antagonist for all tested mutant ARs , with IC50 of 25, 51, 700, and 1160 nM for wtAR, AR(F876L), AR(T877A), and AR(W741L). |
| Name | (S)-3-acetyl-N-(1-(3-(3-chloro-4-cyano-phenyl)-1H-pyrazol-1-yl)propan-2-yl)-1H-pyrazole-5-carboxamide |
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| Synonym | More Synonyms |
| Description | ORM-15341 is a potent and full antagonist for human AR (hAR) with IC50 values of 38 nM as shown by transactivation assays in AR-HEK293 cells stably expressing full-length hAR and an androgen-responsive luciferase reporter gene construct.IC50 value: 38 nMTarget: androgen receptorin vitro: In competitive AR binding assays, the inhibition constant (Ki) values of ORM-15341 was 8 nM. ORM-15341 functions as a full antagonist for all tested mutant ARs , with IC50 of 25, 51, 700, and 1160 nM for wtAR, AR(F876L), AR(T877A), and AR(W741L). |
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| Related Catalog | |
| References |
| Molecular Formula | C19H17ClN6O2 |
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| Molecular Weight | 396.83000 |
| Exact Mass | 396.11000 |
| PSA | 116.46000 |
| LogP | 3.21028 |
| InChIKey | GMBPVBVTPBWIKC-NSHDSACASA-N |
| SMILES | CC(=O)c1cc(C(=O)NC(C)Cn2ccc(-c3ccc(C#N)c(Cl)c3)n2)[nH]n1 |
| Storage condition | 2-8℃ |
| (S)-3-acetyl-N-(1-(3-(3-chloro-4-cyanophenyl)-1H-pyrazol-1-yl)propan-2-yl)-1H-pyrazole-5-carboxamide |
| ORM-15341 |