KB-5492 anhydrous
Modify Date: 2024-01-09 13:39:56
KB-5492 anhydrous structure
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Common Name | KB-5492 anhydrous | ||
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| CAS Number | 129200-10-8 | Molecular Weight | 546.56600 | |
| Density | N/A | Boiling Point | 553.2ºC at 760 mmHg | |
| Molecular Formula | C27H34N2O10 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 288.3ºC | |
Use of KB-5492 anhydrousKB-5492 anhydrous is a potent and selective inhibitor of sigma receptor, inhibits specific [3H]1,3-di(2-tolyl)guanidine (DTG) binding to the sigma receptor with an IC50 of 3.15 μM. KB-5492 anhydrous is an anti-ulcer agent[1][2]. |
| Name | but-2-enedioic acid,(4-methoxyphenyl) 2-[4-[(3,4,5-trimethoxyphenyl)methyl]piperazin-1-yl]acetate |
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| Description | KB-5492 anhydrous is a potent and selective inhibitor of sigma receptor, inhibits specific [3H]1,3-di(2-tolyl)guanidine (DTG) binding to the sigma receptor with an IC50 of 3.15 μM. KB-5492 anhydrous is an anti-ulcer agent[1][2]. |
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| Related Catalog | |
| Target |
IC50: 3.15 μM (sigma receptor)[1] |
| In Vitro | KB-5492 (0.001-100 μM) inhibits specific [3H]DTG binding in a concentration-dependent manner[1]. KB-5492 (0.1-1 mM) significantly and concentration-dependently prevents the ethanol- and acidified aspirin-induced increases in 51Cr release from gastric epithelial cells[2]. |
| In Vivo | KB-5492 (200 mg/kg; p.o.) prevents macroscopic lesions in the gastric mucosa[2]. Animal Model: Male Sprague-Dawley rats weighing 210-240 g are induced gastric mucosal damage[2] Dosage: 200 mg/kg Administration: Oral gavage Result: Reduced the lesion length as compared with the control. Prevented the deep mucosal lesions and exfoliation of surface epithelial cells. |
| References |
| Boiling Point | 553.2ºC at 760 mmHg |
|---|---|
| Molecular Formula | C27H34N2O10 |
| Molecular Weight | 546.56600 |
| Flash Point | 288.3ºC |
| Exact Mass | 546.22100 |
| PSA | 144.30000 |
| LogP | 2.03180 |
| Vapour Pressure | 2.8E-12mmHg at 25°C |