KB-5492 free base

Modify Date: 2025-08-27 00:02:30

KB-5492 free base structure	Common Name	KB-5492 free base
	CAS Number	113594-64-2	Molecular Weight	430.49
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₃H₃₀N₂O₆	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of KB-5492 free base

KB-5492 free base is a potent and selective inhibitor of sigma receptor, inhibits specific [3H]1,3-di(2-tolyl)guanidine (DTG) binding to the sigma receptor with an IC50 of 3.15 μM. KB-5492 free base is an anti-ulcer agent[1][2].

Name	KB-5492 free base

Description	KB-5492 free base is a potent and selective inhibitor of sigma receptor, inhibits specific [3H]1,3-di(2-tolyl)guanidine (DTG) binding to the sigma receptor with an IC50 of 3.15 μM. KB-5492 free base is an anti-ulcer agent[1][2].
Related Catalog	Research Areas >> Inflammation/Immunology Signaling Pathways >> GPCR/G Protein >> Sigma Receptor
Target	IC50: 3.15 μM (sigma receptor)[1]
In Vitro	KB-5492 (0.001-100 μM) free base inhibits specific [3H]DTG binding in a concentration-dependent manner[1]. KB-5492 (0.1-1 mM) free base significantly and concentration-dependently prevents the ethanol- and acidified aspirin-induced increases in 51Cr release from gastric epithelial cells[2].
In Vivo	KB-5492 (200 mg/kg; p.o.) free base prevents macroscopic lesions in the gastric mucosa[2]. Animal Model: Male Sprague-Dawley rats weighing 210-240 g are induced gastric mucosal damage[2] Dosage: 200 mg/kg Administration: Oral gavage Result: Reduced the lesion length as compared with the control. Prevented the deep mucosal lesions and exfoliation of surface epithelial cells.
References	[1]. Harada Y, et, al. Receptor binding profiles of KB-5492, a novel anti-ulcer agent, at sigma receptors in guinea-pig brain. Eur J Pharmacol. 1994 May 2; 256(3): 321-8. [2]. Morimoto Y, et, al. Effects of KB-5492, a new anti-ulcer agent, on ethanol- and acidified aspirin-induced gastric mucosal damage in vivo and in vitro. Jpn J Pharmacol. 1994 Jan; 64(1): 41-7.

Molecular Formula	C₂₃H₃₀N₂O₆
Molecular Weight	430.49
InChIKey	RVYZAZTXLLAVGZ-UHFFFAOYSA-N
SMILES	COc1ccc(OC(=O)CN2CCN(Cc3cc(OC)c(OC)c(OC)c3)CC2)cc1

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Shanghai Nianxing Industrial Co., Ltd
China
Product Name: KB-5492 free base
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Purity: 99.07%
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The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.