KB-5492 free base
Modify Date: 2025-08-27 00:02:30
KB-5492 free base structure
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Common Name | KB-5492 free base | ||
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| CAS Number | 113594-64-2 | Molecular Weight | 430.49 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C23H30N2O6 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of KB-5492 free baseKB-5492 free base is a potent and selective inhibitor of sigma receptor, inhibits specific [3H]1,3-di(2-tolyl)guanidine (DTG) binding to the sigma receptor with an IC50 of 3.15 μM. KB-5492 free base is an anti-ulcer agent[1][2]. |
| Name | KB-5492 free base |
|---|
| Description | KB-5492 free base is a potent and selective inhibitor of sigma receptor, inhibits specific [3H]1,3-di(2-tolyl)guanidine (DTG) binding to the sigma receptor with an IC50 of 3.15 μM. KB-5492 free base is an anti-ulcer agent[1][2]. |
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| Related Catalog | |
| Target |
IC50: 3.15 μM (sigma receptor)[1] |
| In Vitro | KB-5492 (0.001-100 μM) free base inhibits specific [3H]DTG binding in a concentration-dependent manner[1]. KB-5492 (0.1-1 mM) free base significantly and concentration-dependently prevents the ethanol- and acidified aspirin-induced increases in 51Cr release from gastric epithelial cells[2]. |
| In Vivo | KB-5492 (200 mg/kg; p.o.) free base prevents macroscopic lesions in the gastric mucosa[2]. Animal Model: Male Sprague-Dawley rats weighing 210-240 g are induced gastric mucosal damage[2] Dosage: 200 mg/kg Administration: Oral gavage Result: Reduced the lesion length as compared with the control. Prevented the deep mucosal lesions and exfoliation of surface epithelial cells. |
| References |
| Molecular Formula | C23H30N2O6 |
|---|---|
| Molecular Weight | 430.49 |