Suc-Ala-Glu-Pro-Phe-pNA

Modify Date: 2024-01-12 10:50:55

Suc-Ala-Glu-Pro-Phe-pNA Structure
Suc-Ala-Glu-Pro-Phe-pNA structure
Common Name Suc-Ala-Glu-Pro-Phe-pNA
CAS Number 128802-76-6 Molecular Weight 682.678
Density 1.4±0.1 g/cm3 Boiling Point 1165.4±65.0 °C at 760 mmHg
Molecular Formula C32H38N6O11 Melting Point N/A
MSDS N/A Flash Point 658.6±34.3 °C

 Use of Suc-Ala-Glu-Pro-Phe-pNA


Suc-Ala-Glu-Pro-Phe-pNA (Suc-AEPF-pNA) is a chromogenic substrate for the peptidylprolyl isomerase Pin1. Suc-Ala-Glu-Pro-Phe-pNA can be used to evaluate the inhibitory effect of the target compound on Pin1, and catalytic activity of Pin1, etc[1][2].

 Names

Name N-(3-Carboxypropanoyl)-L-alanyl-L-α-glutamyl-L-prolyl-N-(4-nitrophenyl)-L-phenylalaninamide
Synonym More Synonyms

 Suc-Ala-Glu-Pro-Phe-pNA Biological Activity

Description Suc-Ala-Glu-Pro-Phe-pNA (Suc-AEPF-pNA) is a chromogenic substrate for the peptidylprolyl isomerase Pin1. Suc-Ala-Glu-Pro-Phe-pNA can be used to evaluate the inhibitory effect of the target compound on Pin1, and catalytic activity of Pin1, etc[1][2].
Related Catalog
References

[1]. Subedi A, et al. Discovery of novel selenium derivatives as Pin1 inhibitors by high-throughput screening. Biochem Biophys Res Commun. 2016 Jun 3;474(3):528-533.  

[2]. Liu C, et al. Imazamethabenz inhibits human breast cancer cell proliferation, migration and invasion via combination with Pin1. Mol Med Rep. 2017 May;15(5):3210-3214.  

 Chemical & Physical Properties

Density 1.4±0.1 g/cm3
Boiling Point 1165.4±65.0 °C at 760 mmHg
Molecular Formula C32H38N6O11
Molecular Weight 682.678
Flash Point 658.6±34.3 °C
Exact Mass 682.259827
LogP 2.19
Vapour Pressure 0.0±0.3 mmHg at 25°C
Index of Refraction 1.619

 Synonyms

N-(3-Carboxypropanoyl)-L-alanyl-L-α-glutamyl-L-prolyl-N-(4-nitrophenyl)-L-phenylalaninamide
MFCD00238367
L-Phenylalaninamide, N-(3-carboxy-1-oxopropyl)-L-alanyl-L-α-glutamyl-L-prolyl-N-(4-nitrophenyl)-
Suc-Ala-Glu-Pro-Phe-pNA
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