PTUPB
Modify Date: 2024-01-13 23:50:13
PTUPB structure
|
Common Name | PTUPB | ||
|---|---|---|---|---|
| CAS Number | 1287761-01-6 | Molecular Weight | 543.561 | |
| Density | 1.4±0.1 g/cm3 | Boiling Point | N/A | |
| Molecular Formula | C26H24F3N5O3S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of PTUPBPTUPB is a novel dual acting COX-2/sEH inhibitor with IC50 of 1.26 uM/0.9 nM,does not inhibits COX-1 (IC50>100 uM); reduces kidney injury parameters, decreases inflammatory and oxidative stress markers in ZDF rats; exhibits more effective than the same dose of either COX-2 inhibitor (celecoxib) or sEH inhibitor (t-AUCB) alone, shows in vivo antiallodynic activity in vivo; also suppresses glioblastoma growth by targeting EGFR and hyaluronan mediated motility receptor, potentiates the antitumor efficacy of cisplatin. |
| Name | 4-{5-Phenyl-3-[3-({[4-(trifluoromethyl)phenyl]carbamoyl}amino)propyl]-1H-pyrazol-1-yl}benzenesulfonamide |
|---|---|
| Synonym | More Synonyms |
| Description | PTUPB is a novel dual acting COX-2/sEH inhibitor with IC50 of 1.26 uM/0.9 nM,does not inhibits COX-1 (IC50>100 uM); reduces kidney injury parameters, decreases inflammatory and oxidative stress markers in ZDF rats; exhibits more effective than the same dose of either COX-2 inhibitor (celecoxib) or sEH inhibitor (t-AUCB) alone, shows in vivo antiallodynic activity in vivo; also suppresses glioblastoma growth by targeting EGFR and hyaluronan mediated motility receptor, potentiates the antitumor efficacy of cisplatin. |
|---|---|
| References | References 1. Hye Khan MA, et al. Prostaglandins Other Lipid Mediat. 2016 Sep;125:40-7. 2. Li J, et al. Oncotarget. 2017 Sep 15;8(50):87353-87363. 3. Wang F, et al. Mol Cancer Ther. 2018 Feb;17(2):474-483. 4. Hwang SH, et al. J Med Chem. 2011 Apr 28;54(8):3037-50. View Related Products by Target Cyclooxygenase (COX) |
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Molecular Formula | C26H24F3N5O3S |
| Molecular Weight | 543.561 |
| Exact Mass | 543.155212 |
| LogP | 4.91 |
| Index of Refraction | 1.626 |
| 4-{5-Phenyl-3-[3-({[4-(trifluoromethyl)phenyl]carbamoyl}amino)propyl]-1H-pyrazol-1-yl}benzenesulfonamide |
| Benzenesulfonamide, 4-[5-phenyl-3-[3-[[[[4-(trifluoromethyl)phenyl]amino]carbonyl]amino]propyl]-1H-pyrazol-1-yl]- |